International comparison of genomic variations for prognostic factors in chronic kidney disease

慢性肾脏病预后因素基因组变异的国际比较

• 批准号: 23406027
• 负责人: MATSUO Seiichi
• 金额: $ 12.06万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406027/
• 关键词: ゲノムDNAメチル化; 末期腎不全; コホート研究; LUMA法; 炎症; 感染症; 国際研究者交流; スウェーデン; CKD stage5; 遺伝子多型

Inflammation is an established mortality risk factor in chronic kidney disease (CKD) patients and infection may contribution to induce inflammation. Our collaborating Nephrology group in Sweden showed that inflamed uremic Caucasian patients had signs of global DNA hyper-methylation. We have investigated that DNA hyper-methylation is linked to inflammatory markers including a marker of bacterial infections in Japanese CKD patients.Global DNA hyper-methylation was associated with ferritin and procalcitonin as a marker of bacterial infection, suggesting that inflammation induced by subclinical bacterial infection promoted DNA methylation. Moreover, Global DNA hyper-methylation was associated with near future inflammatory status, suggesting a possible axis between hyper-methylation status and present as well as future inflammatory status.These results strongly suggest that to control infection and immune dysfunction due to uremia may be important to induce inflammation in CKD patients.

炎症是慢性肾脏疾病（CKD）患者的既定死亡率风险因素，感染可能会导致炎症。我们在瑞典的合作肾脏科组表明，发炎的尿毒症白种人患者具有全球DNA超甲基化的迹象。我们已经调查了DNA高甲基化与日本CKD患者的细菌感染标记有关的炎症标志物有关。全球DNA DNA高甲基化与铁蛋白和促促阳注素有关，作为细菌感染的标记，这表明由亚细胞细菌感染诱导的炎症促进DNA甲基化。此外，全球DNA高甲基化与不久的将来的炎症状态有关，表明超甲基化状态与现在以及将来的炎症状态之间可能存在轴。诱导CKD患者的炎症。

项目成果

Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.

• DOI: 10.1016/j.humpath.2010.09.015
• 发表时间: 2011-06
• 期刊: Human pathology
• 影响因子: 3.3
• 作者: Shoji Saito;Y. Murakumo;T. Tsuzuki;Atsushi Dambara;Takuya Kato;A. Enomoto;N. Asai;S. Maruyama;S. Matsuo;Masahide Takahashi

脂肪由来間葉系幹細胞を用いた壊死性半月体形成性腎炎への新たな治療法の確立とその作用機序の解明

建立利用脂肪间充质干细胞治疗坏死性新月体肾炎的新方法并阐明其作用机制

• 作者: H. Fukui;R. Uehara;T. Uno and Y. Uno;古橋和拡
• 通讯作者: 古橋和拡

A Novel Regulatory Mechanism of Blood Pressure by Midkine through Epoxyeicosatrienoic Acids (EETs)

Midkine 通过环氧二十碳三烯酸 (EET) 调节血压的新机制

• 作者: Takashi Horiyama;Masashi Kiyomi;Yoshio Okamoto;Ryuhei Uehara;Takeaki Uno;Yushi Uno and Yukiko Yamauchi;Hiroaki Mukaidani;Yuka Sato
• 通讯作者: Yuka Sato

Interaction of B-Type Natriuretic Peptide and Cardiac Troponin T Improves the Prediction of Mortality in Patients on Hemodialysis.

B 型利钠肽和心肌肌钙蛋白 T 的相互作用可改善血液透析患者的死亡率预测。

• 作者: Takehiro Ito;Marcin Kaminski;Hirotaka Ono;Akira Suzuki;Ryuhei Uehara;and Katsuhisa Yamanaka;Ｈｉｒｏａｋｉ Ｍｕｋａｉｄａｎｉ;Kaoru Yasuda
• 通讯作者: Kaoru Yasuda

Fabry病による慢性腎不全で長期に安定した腹膜透析(PD)施行中の一例

法布里病慢性肾功能衰竭长期稳定腹膜透析（PD）1例

• 发表时间: 2013
• 作者: 武藤玲子;勝野敬之;鈴木康弘;安田香;尾崎武徳;小杉智規;安田宜成;佐藤和一;坪井直毅;水野正司;伊藤恭彦;丸山彰一;松尾清一
• 通讯作者: 松尾清一