Asian Collaborative Study for Creation of GFR Estimation Equation (ACOS-CG-FREE)

创建 GFR 估计方程的亚洲合作研究 (ACOS-CG-FREE)

• 批准号: 18406032
• 负责人: MATSUO Seiichi
• 金额: $ 8.17万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406032/
• 关键词: chronic kidney disease (CKD); glomerular filtration rate (GFR); GFR equation; inulin clearance; 糸球体濾過値(GFR); 国際情報交換; 韓国:中国

Glomerular filtration rate (GFR) Project by Japanease Society of Nephrology was carried among 80 collaborating centers all over Japan and new Japanese GFR equations were developed in 413 participants and validated in 350 participants. In our study, GFR was evaluated in 95 Japanese cases.Protocol of inulin clearance (Cin) was simplified in this study. In the standard method, GFR is evaluated by 3 sets of Cin for 30 minutes, which is not practical in clinical use. GFR evaluated with 2 consecutive Cin for 30 minutes was compared to those with 3 consecutive one in 737 cases. GFR by 2 consecutive Cin showed high correlation coefficients against GFR by 3 Cin tests (r=0.988). Root mean square error (RMSE) was 5.3 ml/min per 1.73 m^2. Therefore, GFR was evaluated by simplified Cin protocol with 2 consecutive Cin tests in this study.Doctor driven clinical trials of Cin tests were conducted in Korea and Taiwan. Using simplified Cin protocol, GFR was evaluated in 113 Korean and 200 Taiwanese cases and Japanse GFR equation was validated. All samples were assayed in a central laboratory in Japan. No severe adverse event by Cin test was reported. Accuracy within 30% of measured GFR was 74% for Japanese equation, which is greater than that of MDRD or Cockroft-Gault equation.In conclusion, Japanese GFR equation are more accurate for the Korean and Taiwanese population than the previously reported equations.

日本肾病学会的肾小球滤过率 (GFR) 项目在日本各地的 80 个合作中心进行，新的日本 GFR 方程在 413 名参与者中开发，并在 350 名参与者中得到验证。在我们的研究中，对 95 个日本病例的 GFR 进行了评估。本研究简化了菊粉清除 (Cin) 的方案。标准方法中，GFR是通过3组Cin评估30分钟，这在临床使用中并不实用。在 737 例病例中，将连续 2 次 Cin 30 分钟评估的 GFR 与连续 3 次 Cin 评估的 GFR 进行了比较。 2 个连续 Cin 测试的 GFR 与 3 个 Cin 测试的 GFR 显示出高相关系数 (r=0.988)。均方根误差 (RMSE) 为每 1.73 m^2 5.3 ml/min。因此，本研究中通过简化的Cin方案和连续2次Cin测试来评估GFR。在韩国和台湾进行了由医生驱动的Cin测试临床试验。使用简化的 Cin 协议，对 113 例韩国和 200 例台湾病例的 GFR 进行了评估，并验证了日本 GFR 方程。所有样本均在日本的中心实验室进行检测。 Cin 试验未报告严重不良事件。日本方程在测量 GFR 30% 范围内的准确度为 74%，高于 MDRD 或 Cockroft-Gault 方程。 总之，日本 GFR 方程对于韩国和台湾人群比之前报道的方程更准确。

项目成果

Cardiac Troponin T Predicts Long-Term Cardiovascular Morbidity and Mortality in chronic Kidney Disease Patients on Maintenance Hemodialysis.

心肌肌钙蛋白 T 可预测维持性血液透析的慢性肾病患者的长期心血管发病率和死亡率。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima
• 通讯作者: Shigejiro Iwashima

Estimation of Japanese CKD Population by a Modified MDER Equation

通过修正的 MDER 方程估算日本 CKD 人口

• 发表时间: 2006
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita;Tomoki Kosugi;Enyu Imai;Tomoki Kosugi;Kaoru Yasuda;Yukio Yuzawa;Enyu Imai
• 通讯作者: Enyu Imai

Chemically modified siRNA prolonged RNA interference in renal disease

• DOI: 10.1016/j.bbrc.2007.08.189
• 发表时间: 2007-11-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takabatake, Yoshitsugu;Isaka, Yoshitaka;Imai, Enyu
• 通讯作者: Imai, Enyu

Possible Involvement of a VEGF Receptor Subtype-Dependent Mechanism in the Pathogenesis of Diabetic Nephropathy in the Cell-Specific Calmodulin Overexpressing Mice (CaMTg).

VEGF 受体亚型依赖性机制可能参与细胞特异性钙调蛋白过表达小鼠 (CaMTg) 糖尿病肾病的发病机制。

• 发表时间: 2006
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita;Tomoki Kosugi;Enyu Imai;Tomoki Kosugi;Kaoru Yasuda;Yukio Yuzawa
• 通讯作者: Yukio Yuzawa

Modification of the IDMS MDRD Study Equation for Japanese.

针对日语的 IDMS MDRD 研究方程的修改。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio
• 通讯作者: Masaru Horio