Asian Collaborative Study for Creation of GFR Estimation Equation (ACOS-CG-FREE)

创建 GFR 估计方程的亚洲合作研究 (ACOS-CG-FREE)

• 批准号: 18406032
• 负责人: MATSUO Seiichi
• 金额: $ 8.17万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406032/
• 关键词: chronic kidney disease (CKD); glomerular filtration rate (GFR); GFR equation; inulin clearance; 糸球体濾過値(GFR); 国際情報交換; 韓国:中国

Glomerular filtration rate (GFR) Project by Japanease Society of Nephrology was carried among 80 collaborating centers all over Japan and new Japanese GFR equations were developed in 413 participants and validated in 350 participants. In our study, GFR was evaluated in 95 Japanese cases.Protocol of inulin clearance (Cin) was simplified in this study. In the standard method, GFR is evaluated by 3 sets of Cin for 30 minutes, which is not practical in clinical use. GFR evaluated with 2 consecutive Cin for 30 minutes was compared to those with 3 consecutive one in 737 cases. GFR by 2 consecutive Cin showed high correlation coefficients against GFR by 3 Cin tests (r=0.988). Root mean square error (RMSE) was 5.3 ml/min per 1.73 m^2. Therefore, GFR was evaluated by simplified Cin protocol with 2 consecutive Cin tests in this study.Doctor driven clinical trials of Cin tests were conducted in Korea and Taiwan. Using simplified Cin protocol, GFR was evaluated in 113 Korean and 200 Taiwanese cases and Japanse GFR equation was validated. All samples were assayed in a central laboratory in Japan. No severe adverse event by Cin test was reported. Accuracy within 30% of measured GFR was 74% for Japanese equation, which is greater than that of MDRD or Cockroft-Gault equation.In conclusion, Japanese GFR equation are more accurate for the Korean and Taiwanese population than the previously reported equations.

日本肾脏学协会的肾小球滤过率（GFR）项目在日本的80个合作中心中进行了，在413名参与者中开发了新的日本GFR方程，并在350名参与者中进行了验证。在我们的研究中，在95例日本病例中对GFR进行了评估。在本研究中简化了无蛋白清除率（CIN）。在标准方法中，GFR通过3组CIN评估30分钟，这在临床使用中是不切实际的。将连续2个CIN评估的GFR与737例中连续3例的GFR进行了30分钟的比较。 GFR连续2个CIN通过3个CIN测试显示与GFR的高相关系数（r = 0.988）。均方根误差（RMSE）为每1.73 m^2的5.3 ml/min。因此，在这项研究中，通过简化的CIN协议对GFR进行了2个连续的CIN测试评估。在韩国和台湾进行了CIN测试的Doctor驱动临床试验。使用简化的CIN协议，在113韩语和200个台湾案件中评估了GFR，并验证了日本GFR方程。所有样品均在日本的一个中央实验室进行测定。 CIN测试没有严重的不良事件。对于日本方程式，测得的GFR的30％以内的准确性比MDRD或Cockroft-Gault方程的准确性为74％。总之，对于韩国和台湾人口而言，日本GFR方程比以前报道的方程式更准确。

项目成果

Estimation of Japanese CKD Population by a Modified MDER Equation

通过修正的 MDER 方程估算日本 CKD 人口

• 发表时间: 2006
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita;Tomoki Kosugi;Enyu Imai;Tomoki Kosugi;Kaoru Yasuda;Yukio Yuzawa;Enyu Imai
• 通讯作者: Enyu Imai

Cardiac Troponin T Predicts Long-Term Cardiovascular Morbidity and Mortality in chronic Kidney Disease Patients on Maintenance Hemodialysis.

心肌肌钙蛋白 T 可预测维持性血液透析的慢性肾病患者的长期心血管发病率和死亡率。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima
• 通讯作者: Shigejiro Iwashima

Chemically modified siRNA prolonged RNA interference in renal disease

• DOI: 10.1016/j.bbrc.2007.08.189
• 发表时间: 2007-11-16
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takabatake, Yoshitsugu;Isaka, Yoshitaka;Imai, Enyu
• 通讯作者: Imai, Enyu

Possible Involvement of a VEGF Receptor Subtype-Dependent Mechanism in the Pathogenesis of Diabetic Nephropathy in the Cell-Specific Calmodulin Overexpressing Mice (CaMTg).

VEGF 受体亚型依赖性机制可能参与细胞特异性钙调蛋白过表达小鼠 (CaMTg) 糖尿病肾病的发病机制。

• 发表时间: 2006
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio;Yutaka Fujita;Tomoki Kosugi;Enyu Imai;Tomoki Kosugi;Kaoru Yasuda;Yukio Yuzawa
• 通讯作者: Yukio Yuzawa

Modification of the IDMS MDRD Study Equation for Japanese.

针对日语的 IDMS MDRD 研究方程的修改。

• 发表时间: 2007
• 作者: R.Ahlswede;et al.(eds.);分担執筆 H.Nagaoka 他;Schmid H.;Imai E.;Shoji T.;Imai E.;Kanamaru Y.;Yoshimichi Urahama;Kaoru Yasuda;Takenori Ozaki;Kaoru Yasuda;Enyu Imai;Yutaka Fujita;Shigejiro Iwashima;Tomoki Kosugi;Waichi Sato;Masaru Horio
• 通讯作者: Masaru Horio