Pathophysiological mechanisms in sarcopenic obesity

少肌性肥胖的病理生理机制

• 批准号: 23390188
• 负责人: KOHARA Katsuhiko
• 金额: $ 12.23万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390188/
• 关键词: 内臓肥満; サルコペニア; 動脈スティフネス; 機能障害; 代謝異常; アディポカイン; 肥満; 動脈硬化; 老化因子; モデル動物; プレ・フレイルティ; 認知機能; サルコペニック肥満; 重心動揺; 起立性低血圧; 縦断研究; 起立性血圧変動

We proposed the definition of sarcopenia and sarcopenic obesity. Three aspects of sarcopenic obesity, 1) metabolic abnormality, 2) functional change, and 3) causality, were investigated.1) Metabolic abnormality; Sarcopenic obesity is associated with insulin resistance, leptin resistance, and adiponectin paradox. Sarcopenia is also involved in the BNP resistance observed in obese subjects.2) Functional changes; Sarocopenia was related to frailty, arterial stiffness, central blood pressure and end organ damages. 3)Causalty; Several candidate genes for sarcopenia were identified including KCNQ1 and CHD13. We demonstrated ectopic fat infiltration in the skeletal muscle in cardiotoxin injury model of ob/ob and KKAy mouse. Causal relationship between sarcopenic obesity and cardiovascular events will be followed in longitudinal study.

我们提出了肌少症和肌少症肥胖的定义。研究了少肌性肥胖的三个方面，1）代谢异常，2）功能改变，3）因果关系。1）代谢异常；少肌性肥胖与胰岛素抵抗、瘦素抵抗和脂联素悖论有关。肌肉减少症也与肥胖受试者中观察到的 BNP 抵抗有关。2) 功能变化；肌肉减少症与虚弱、动脉僵硬、中枢血压和终末器官损伤有关。 3）伤亡；确定了一些肌肉减少症的候选基因，包括 KCNQ1 和 CHD13。我们在 ob/ob 和 KKAy 小鼠心脏毒素损伤模型中证明了骨骼肌中的异位脂肪浸润。纵向研究将追踪少肌性肥胖与心血管事件之间的因果关系。

项目成果

Serum Gamma-Glutamyl Transferase within Its Normal Concentration Range Is Related to the Presence of Impaired Fasting Glucose and Diabetes among Japanese Community-Dwelling Persons

• DOI: 10.3109/07435800.2010.534756
• 发表时间: 2011-01-01
• 期刊: ENDOCRINE RESEARCH
• 影响因子: 2.1
• 作者: Kawamoto, Ryuichi;Tabara, Yasuharu;Abe, Masanori
• 通讯作者: Abe, Masanori

The association between blood pressure and cognitive function

血压与认知功能之间的关系

• DOI: 10.1017/s0959259810000444
• 发表时间: 2011
• 期刊: Reviews in clinical gerontology
• 作者: Igase M;Kohara K;他
• 通讯作者: 他

Liver enzyme and adipocytokine profiles are synergistically associated with insulin resistance: the J-SHIPP study.

• DOI: 10.5551/jat.11924
• 发表时间: 2012
• 期刊: Journal of atherosclerosis and thrombosis
• 影响因子: 4.4
• 作者: Eri Uetani;Y. Tabara;M. Igase;T. Kido;Namiko Ochi;Rie Takita;K. Kohara;T. Miki

Central Blood Pressure and End-organ Damage

• DOI: 10.2174/157340212800840636
• 发表时间: 2012-01-01
• 期刊: CURRENT HYPERTENSION REVIEWS
• 影响因子: 2.3
• 作者: Kohara, Katsuhiko

Increased levels of soluble p3-Alcadeinain plasma of patients with Alzheimer's disease

阿尔茨海默病患者血浆中可溶性 p3-Alcadeinain 水平升高

• 发表时间: 2011
• 作者: KamogawaK、Kohara K;他
• 通讯作者: 他