Comprehensive studies on chronic infection with Chlamydia pneumoniae as a risk factor for atherosclerosis

肺炎衣原体慢性感染作为动脉粥样硬化危险因素的综合研究

• 批准号: 14570668
• 负责人: KOHARA Katsuhiko
• 金额: $ 1.79万
• 依托单位: EHIME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570668/
• 关键词: Chlamydia pneumoniae; chronic infection; seropositivity; adhesion molecule; chemokine; oxidative stress; susceptible gene; angiotensinogen; MTHFR; GS蛋白αサブユニット; 一塩基多型; 環境因子・遺伝因子相互作用; 動脈硬化; 疾患感受性遺伝子; 関連研究; ゲノムワイド・スクリーニング; マイクロサテライトマーカー

Chronic and persistent infection a risk factor for atherosclerosis has been the focus of research. In particular, Chlamydia pneumoniae(Cp), has attracted so much attention that several clinical trials using antimicrobial drugs have been carried out. Although infection and activation of vascular endothelium by micropathogen is one of main underlying mechanisms, the mechanisms how the infection turns out to persist in certain patients after pulmonary airways infections remains to be determined. Three major results were obtained in the present study : (1)Cp seropositivity showed a significant positive associations with soluble adhesion molecules, ICAM-1 and VCAM-1,as well as chemokines MCP1 concentration, (2)Cp seroposivity significantly associated with systemic oxidative stress expressed with urinary concentration of 8-epi PGF2 alfa, and (3)Cp seropositivity was significantly associated with M235T angiotensinogen gene polymorphisms. These findings provide useful information for the comprehensive understanding about the mechanisms linking Cp infection and atherosclerosis.

慢性和持续感染是动脉粥样硬化的危险因素，一直是研究的焦点。尤其是肺炎衣原体（Cp），引起了人们的广泛关注，已经开展了多项使用抗菌药物的临床试验。尽管微病原体感染和激活血管内皮是主要的潜在机制之一，但肺部气道感染后感染在某些患者中持续存在的机制仍有待确定。本研究获得了三个主要结果：（1）Cp血清阳性率与可溶性粘附分子、ICAM-1和VCAM-1以及趋化因子MCP1浓度呈显着正相关，（2）Cp血清阳性率与全身氧化显着相关应激以尿中 8-epi PGF2 alfa 浓度表达，(3)Cp 血清阳性与 M235T 血管紧张素原基因显着相关多态性。这些发现为全面了解 Cp 感染与动脉粥样硬化的机制提供了有用的信息。

项目成果

Kohara K, Tabara Y, 他: "Chlamydia pneumoniae seropositivity is associated with increased plasma levels of soluble cellular adhesion molecules in community-dwelling subjects : J-SHIPP the Shimanami Health Promoting Program (J-SHIPP) study."Stroke. 33. 1474

Kohara K、Tabara Y 等人：“肺炎衣原体血清阳性与社区居民体内可溶性细胞粘附分子血浆水平升高有关：J-SHIPP 岛波健康促进计划 (J-SHIPP) 研究。”中风 33。 1474

Wu Z, Kohara K, 他: "Genome-wide linkage disequilibrium mapping of hypertension in Japan"Hypertension Research. 26. 533-540 (2003)

Wu Z、Kohara K 等：“日本高血压的全基因组连锁不平衡图谱”高血压研究 26. 533-540 (2003)。

Kohara, K., et al.: "Chlamydia pneumoniae Seropositivity is Associated with Increased Plasma Levels of Soluble Cellular Adhesion Molecules in Community-Dwelling Subjects: J-SHIPP"Stroke. 33. 1474-1479 (2002)

Kohara, K. 等人：“肺炎衣原体血清阳性与社区居住受试者中可溶性细胞粘附分子血浆水平升高相关：J-SHIPP”中风。

Kohara K, Fujisawa M, et al.: "MTHFR Gene Polymorphism as Risk Factor for Silent Brain Infarcts and White Matter Lesions in Japanese General Population: NILS-LSA Study"Stroke. 34. 1130-1135 (2003)

Kohara K、Fujisawa M 等人：“MTHFR 基因多态性作为日本普通人群无症状脑梗塞和白质病变的危险因素：NILS-LSA 研究”中风。

Jin JJ, Kohara K, et al.: "Association of endothelin-1 gene variant with hypertension"Hypertension. 41. 163-167 (2002)

Jin JJ，Kohara K，等：“内皮素-1基因变异与高血压的关联”高血压。