Development of study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes

FGFR2相关颅缝早闭综合征的研究模型和治疗流程的建立

• 批准号: 22659363
• 负责人: MORI Shiro
• 金额: $ 2.04万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659363/
• 关键词: FGFR2; 疾患モデル; 関節強直症; ナノバブル; 超音波; 分子導入; 生物製剤; 遺伝子解析; プラスミドDNA; FGFR2; 疾患モデル; 関節強直症; ナノバブル; 超音波; 分子導入; 生物製剤; 遺伝子解析; プラスミドDNA

The aim of the present study is to develop a study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes. In the present study, a new recombinant congenic strain of mice, which is a model for the dysplasia of bone and cartilage, was successfully established, and the onset of the disease in the mice was significantly associated with the genetic locus of FGFR2. By using the animal model and gene delivery system to the tissue around bone using nanobubbles and ultrasound, it became to be possible to perform an experimental molecular therapy using the Ig-Fc fusion protein of FGFR2 against the study model for the FGFR-related dysplasia of bone and cartilage.

本研究的目的是针对FGFR2相关的颅内突变综合征开发研究模型和医疗程序。在本研究中，成功​​建立了一种新的重组小鼠的重组先天性菌株，该菌株是骨和软骨发育异常的模型，小鼠的疾病发作与FGFR2的遗传位点显着相关。通过使用纳米泡和超声使用动物模型和基因递送系统，将动物模型和基因递送系统与骨骼周围的组织一起使用，可以使用FGFR2的IG-FC融合蛋白对FGFR相关的骨骼和软骨的研究模型进行实验性分子疗法。