Stretch of muscle sarcomere induces protrusion of myosinheads toward actin so as to facilitate formation of contractile cross-bridges.

肌肉肌节的拉伸诱导肌球蛋白头向肌动蛋白突出，从而促进收缩性横桥的形成。

• 批准号: 22616008
• 负责人: TAKEMORI Shigeru
• 金额: $ 2.75万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22616008/
• 关键词: 横紋筋; エックス線回折; 収縮; 筋節; X線回折; スキンドファイバー; 骨格筋; 心筋; ゲルゾリン; ミオシン; サルコメア; アクチン; Spring8; ブタンジオンモノオキシム

Stretch of sarcomeres of striated muscle induces higher contractile activity in striated muscle. Well organized fine structure of sarcomere is responsible to this stretch activation phenomenon, but its detailed mechanism has not been elucidated. Developing two-dimensional x-ray diffraction techniques, we found that stretch induces protrusion of myosin heads out of the thick filament backbone toward the neighboring actin molecules on thin filament so as to facilitate formation of contractile cross-bridges between myosin heads and actin molecules.

横纹肌肉的肉瘤拉伸会诱导横纹肌肉中的收缩活性较高。组织良好的精细结构是对这种拉伸激活现象负责的，但尚未阐明其详细机制。开发了二维X射线衍射技术，我们发现伸展运动会诱导肌球蛋白头从厚细丝的厚细丝主链伸出薄丝上的邻近肌动蛋白分子，从而促进肌球蛋白头和肌动蛋白分子之间的收缩跨支架形成。

项目成果

横紋筋サルコメアのフィラメント格子の安定性

横纹肌肌节丝晶格的稳定性

• 发表时间: 2013
• 作者: Li Q;et al.;竹森 重
• 通讯作者: 竹森 重

Structure and function of skeletal muscle and locomotive systems: Involvement of water-state transitions

骨骼肌和运动系统的结构和功能：水态转变的参与

• 发表时间: 2012
• 期刊: J. Physical Fitness Sport Med
• 作者: Takemori S;Kimura M
• 通讯作者: Kimura M

Structure and function of skeletal muscle and locomotive systems : Involvement of water-state transitions

骨骼肌和运动系统的结构和功能：水态转变的参与

• 发表时间: 2012
• 期刊: J Phys Fitness Sports Med
• 作者: Takemori S;Kimura M
• 通讯作者: Kimura M