A role of Wnt/beta-catenin signal network on the stimulated bone formation under mechanical stress.
Wnt/β-连环蛋白信号网络对机械应力下刺激骨形成的作用。
基本信息
- 批准号:22592036
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We can stimulate bone formation with tensile stress on a suture of mouse calvaria. Gene expressions of many factors, especially Wnt/beta-catenin family which are involved in bone-cell activity were examined during the stimulated bone formation. We could show the relative expression ratios of some factors at each time point of the experiment. Those results suggested which factors were more important at each stage of the stimulated bone formation.
我们可以在小鼠瓦尔瓦里亚的缝合线上以拉伸应力刺激骨形成。在刺激的骨形成过程中检查了许多因素的基因表达,尤其是参与骨细胞活性的Wnt/β-catenin家族。我们可以在实验的每个时间点显示某些因素的相对表达比。这些结果表明,哪些因素在刺激骨形成的每个阶段更为重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A comprehensive analysis of mechanical stress-regulated gene expression in mouse cranial sutures
小鼠颅骨缝机械应力调节基因表达的综合分析
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:Mika Ikegame (代 表);Mariko Kawai;Yoshiaki Tabuchi;Yukihiro Furusawa;Takashi Kondo;Masaki Nakano;Atsuhiko Hattori and Toshio Yamamoto
- 通讯作者:Atsuhiko Hattori and Toshio Yamamoto
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IKEGAME Mika其他文献
IKEGAME Mika的其他文献
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{{ truncateString('IKEGAME Mika', 18)}}的其他基金
Interactive effetcs of melatonin and mechanical stress on bone cells
褪黑激素和机械应力对骨细胞的相互作用
- 批准号:
25462853 - 财政年份:2013
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Morphological studies on cytoskeleton and adherent molecules of the cells in mechanically stretched bone sutures
机械拉伸骨缝细胞的细胞骨架和粘附分子的形态学研究
- 批准号:
19592112 - 财政年份:2007
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The role of cell cortex structures in mechanical stress signal transduction in osteoblasts.
细胞皮层结构在成骨细胞机械应力信号转导中的作用。
- 批准号:
16591822 - 财政年份:2004
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Possible roles of adhesion complex and cytoskeleton as a mechano-receptor in osteoblasts.
粘附复合物和细胞骨架作为成骨细胞中的机械受体的可能作用。
- 批准号:
14571729 - 财政年份:2002
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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