Experimental study of suprachoroidal drug delivery

脉络膜上腔给药的实验研究

• 批准号: 22591933
• 负责人: HAYASHI Atsushi
• 金额: $ 2.91万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591933/
• 关键词: 眼組織学; ドラッグデリバリー; 後眼部

We designed a method to deliver drugs into the eye for a relatively long term by delivering collagen gel and steroid into the suprachoroidal space between the sclera and the choroid. We examined the injected collagen gel histologically. As results, we found the collagen gel disappeared from the suprachoroidal space by 3 months after injection. The intraocular concentrations of the steroid mixed with the collagen gel were not significantly different from those of the steroid only during 3 months.

我们设计了一种通过将胶原蛋白凝胶和类固醇输送到巩膜和脉络膜之间的胶原蛋白凝胶和类固醇中，将药物输送到眼睛中的方法相对长。我们在组织学上检查了注入的胶原蛋白凝胶。结果，我们发现注射后3个月后，胶原蛋白凝胶从甲状腺上空间中消失了。类固醇与胶原蛋白凝胶混合的眼内浓度仅在3个月内与类固醇的浓度没有显着差异。

项目成果

Histologic changes in the Retina and the Choroid After Atelocollagen Gel Injection into the Suprachoroidal Space of Rabbit Eyes.

兔眼脉络膜上腔注射去端肽胶原凝胶后视网膜和脉络膜的组织学变化。

• 发表时间: 2013
• 作者: Hayashi A.;and Sato S
• 通讯作者: and Sato S