Epidemiology of biomarker for heart failure screening

心力衰竭筛查生物标志物的流行病学

• 批准号: 22790557
• 负责人: YAMAGISHI Kazumasa
• 金额: $ 2.5万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790557/
• 关键词: 成人保健; 心不全; 疫学; バイオマーカー; NT-proBNP; 心房細動; 心電図異常; うっ血性心不全; 疫学研究; 循環器疾患; 成人保健; 心不全; 疫学; バイオマーカー; NT-proBNP; 心房細動; 心電図異常; うっ血性心不全; 疫学研究; 循環器疾患

We performed an epidemiological study of biomarker of congestive heart failure in Japanese communities. We measured N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP), a biomarker of heart failure, among Japanese population. The subjects were 3,545 men and women ages 30 or more in two Japanese communities. NT-proBNP distributed 59% for 0-54, 29% for 55-124, 11% for 125-499, 1% for 500-949, and 0.5% for 950 or more. NT-proBNP was correlated with age across the NT-proBNP categories below 500, and plataued thereafter. NT-proBNP was also correlated with the prevalence of hypertension below NT-proBNP of 950, and dropped down thereafter. Prevalences of diabetes treatment, heart disease treatment, atrial fibrillation, and symptoms of nocturnal dyspnoea and dyspnoea on exertion were also correlated generally with NT-proBNP. Abnormal electrocardiogram (defined as abnormal Q, ST-T change, complete left bundle branch block and/or atrial fibrillation) was strongly correlated with NT-proBNP.In conclusion, NT-proBNP was correlated with several cardiovascular risk factors, especially with atrial fibrillation and abnormal electrocardiogram among Japanese population. Although the prevalence of persons with high NT-proBNP (.500pg/ml) was not necessarily high (2%), measuring NT-proBNP in community health checkup settings would be useful to prevent congestive heart failure with effective health education program for people with intermediate level of NT-proBNP (125-499pg/ml).

我们对日本社区充血性心力衰竭的生物标志物进行了一项流行病学研究。我们测量了日本人群中激素激素型脑型纳二肽（NT-Probnp）的N末端片段，这是心力衰竭的生物标志物。在两个日本社区中，受试者是3,545名30岁以上的男女。 NT-ProBNP的0-54分配了59％，为55-124，为29％，为125-499分配11％，为500-949的1％，为950或更多的0.5％。 NT-ProBNP与500岁以下的NT-ProBNP类别的年龄相关，此后Plataued。 NT-ProBNP还与低于NT-Probnp低于950的高血压的患病率相关，此后下降。锻炼时糖尿病治疗，心脏病治疗，心房颤动以及夜间呼吸困难和呼吸困难的症状也普遍与NT-ProBNP相关。异常心电图（定义为异常Q，ST-T变化，完整的左束分支区块和/或房颤）与NT-ProBNP.IN结论密切相关，NT-ProBNP与多个心血管危险因素相关，尤其是与动作纤维纤维和亚abnormal expranmal Electrocartagimals Messoparemals Meseruemals Measesemalal superactagienagion。尽管高NT-Probnp（.500pg/ml）患者的患病率不一定很高（2％），但在社区健康检查环境中测量NT-ProBNP将有助于防止NT-Probnp中等水平的人（125-499pg/m​​l）的有效健康教育计划。