The role of the anti-apoptotic effect of angiogenin in vascular homeostasis

血管生成素的抗凋亡作用在血管稳态中的作用

• 批准号: 22791978
• 负责人: IBARAGI Soichiro
• 金额: $ 2.58万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791978/
• 关键词: 口腔外科学一般; 血管新生

To determine the physiological function of angiogenin(ANG), by making ANG gene inoperative, ANG knockout(KO) mice were created. Vascular endothelial(VE) cells were isolated from liver from wild type and KO mice, respectively. The growth of VE cells from KO mice(KOVE cells) was more suppressed than the one of VE cells from wild type mice. In serum-starved condition, KOVE cells were sensitive to stress and induced to apoptosis. ANG was found to be anti-apoptotic. Angiogenesis was suppressed in KO mice. Therefore, we shed light on the role of the anti-apoptotic effect of ANG in vascular homeostasis and angiogenesis.

为了确定血管生成素（ANG）的生理功能，通过使ANG基因失活，制备ANG基因敲除（KO）小鼠。分别从野生型和KO小鼠的肝脏中分离出血管内皮(VE)细胞。 KO小鼠的VE细胞（KOVE细胞）的生长比野生型小鼠的VE细胞的生长受到更多抑制。在血清饥饿条件下，KOVE 细胞对应激敏感并诱导细胞凋亡。发现ANG具有抗细胞凋亡作用。 KO 小鼠的血管生成受到抑制。因此，我们阐明了 ANG 的抗凋亡作用在血管稳态和血管生成中的作用。

项目成果

Hypoxia-induced up-regulation of angiogenin is related to progression oforal cance

缺氧诱导的血管生成素上调与口腔癌的进展有关

• 期刊: Oral Oncol
• 影响因子: 4.8
• 作者: Kishimoto K;Yoshida S;Ibaragi S;Okui T;Yoshioka N;Shimo T;Hu GF;Sasaki
• 通讯作者: Sasaki

Does angiogenin have an important role in the cancer-induced osteolysis of oral squamous cell carcinoma?

血管生成素在口腔鳞状细胞癌诱导的骨质溶解中是否具有重要作用？

• 发表时间: 2010
• 作者: 引地尚子;近津大地;西條英人;小笠原徹;森良之;飯野光喜;須佐美隆史;高戸毅;青木香澄
• 通讯作者: 青木香澄

Angiogeninの発現亢進は口腔癌の増殖と進展に関与する

血管生成素表达增加参与口腔癌的生长和进展

• 发表时间: 2011
• 作者: Hayashido Y;Hamana T;Ishida Y;Shintani T;Koizumi K;Okamoto T.;岸本晃治
• 通讯作者: 岸本晃治

Induction of MMP-13 Expression in Bone-metastasizing Cancer Cells by Type I Collagen through Integrinα1β1 andα2β1-p38 MAPK Signaling

I 型胶原通过整合素α1β1 和α2β1-p38 MAPK 信号传导诱导骨转移癌细胞中 MMP-13 的表达

• 发表时间: 2011
• 期刊: Anticancer Research
• 影响因子: 2
• 作者: Soichiro Ibaragi;Tsuyoshi Shimo;Masahiro Iwamoto;Nur Mohammad Monsur Hassan;Sachiko Isowa;Naito Kurio;Hiroki Mandai;Shinichi Kodama;Akira Sasaki.
• 通讯作者: Akira Sasaki.