Regulation mechanism of antigen recognition by controlling the interaction of dendritic cells and mucosal cells in the epithelium

控制上皮树突状细胞与粘膜细胞相互作用调节抗原识别机制

• 批准号: 22791615
• 负责人: KUROSE Makoto
• 金额: $ 2.58万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791615/
• 关键词: 特異的免疫療法; 樹状細胞; テロメラーゼ遺伝子導入培養ヒト粘膜上皮細胞; 特異的免疫反応

Nasopharynx and nasal mucosa are located at the forefront of the host defense against foreign pathogens, which plays an important role in acquired immunity and innate immunity. To elucidate the immune system of allergy infection, we analyzed the mechanism of epithelial barrier function and antigen presentation in the nasal epithelium of human nasopharyngeal epithelium. In addition, we made a research on the interaction of dendritic cells and mucosal epithelium.

鼻咽和鼻粘膜位于宿主防御外来病原体的最前沿，在获得性免疫和先天性免疫中发挥着重要作用。为了阐明过敏感染的免疫系统，我们分析了人鼻咽上皮的上皮屏障功能和抗原呈递的机制。此外，我们还对树突状细胞和粘膜上皮的相互作用进行了研究。