Functional analysis of MIF in brain tumor initiating cell

MIF在脑肿瘤起始细胞中的功能分析

• 批准号: 22791356
• 负责人: FUKAYA Raita
• 金额: $ 2.5万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791356/
• 关键词: 脳腫瘍幹細胞; グリオーマ; 脳腫瘍; 脳腫瘍幹細胞; グリオーマ; 脳腫瘍

In this study, we performed the functional analysis of MIF in glioma and brain tumor stem cells(BTSCs). Knockdown of MIF suppressed the cell proliferation in glioma and the effect was dependent on p53 expression. MIF was shown to bind p53 and inhibit its functions as a tumor suppressor in glioma cells. Moreover, MIF knockdown inhibited not only in vitro cell growth, but also in vivo tumor growth in BTSCs. These results suggest that MIF can be a target for the treatment of BTSCs.

在这项研究中，我们对神经胶质瘤和脑肿瘤干细胞（BTSC）进行了MIF的功能分析。 MIF的敲低抑制了神经胶质瘤的细胞增殖，其作用取决于p53的表达。显示MIF结合p53并抑制其作为神经胶质瘤细胞中肿瘤抑制的功能。此外，MIF敲低不仅抑制了体外细胞的生长，还抑制了BTSC中体内肿瘤的生长。这些结果表明，MIF可以成为治疗BTSC的目标。