The elucidation of the mechanism and pathogenesis of severe drug eruption.

阐明重症药疹的机制和发病机制。

• 批准号: 22791085
• 负责人: TAKAHASHI Ryo
• 金额: $ 2.5万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791085/
• 关键词: regulatory T cell; SJS; TEN; マイコプラズマ肺炎; 皮膚免疫

Mycoplasma pneumoniae(MP) infection is related in the pathogenesis of Stevens-Johnson syndrome(SJS) which is severe drug eruption. However, its causal relationship is unclear. We previously found that the functional activity of regulatory T(Treg) cells was impaired in the acute stage of SJS. We therefore investigated whether Treg cells were related to development of SJS. The functional activity of Tregs was profoundly impaired during the acute phase of infection with MP, varicella-zoster virus, and parvovirus B19.In particular, the impaired Treg function was associated with a decrease in the CCR6+Tregs in infection with MP but not with other viral infections. Upon resolution, however, the impaired Treg function had been restored in viral infections, while it remained abrogated even 1year after infection with MP. Our findings suggest that MP infections could serve to enhance the risk of subsequently developing severe allergic diseases by chronically abrogating Treg-mediated suppression.

支原体肺炎（MP）感染与史蒂文斯 - 约翰逊综合征（SJS）的发病机理有关，这是严重的药物喷发。但是，其因果关系尚不清楚。我们先前发现，在SJS的急性阶段，调节T（Treg）细胞的功能活性受损。因此，我们研究了Treg细胞是否与SJS的发展有关。在用MP，水疗系带病毒和细小病毒B19的急性感染期间，Treg的功能活性严重受损，尤其是Treg功能受损与MP感染中CCR6+Treg的降低有关，但与其他病毒感染没有。然而，通过分辨率，Treg功能受损已在病毒感染中恢复，而用MP感染后，它仍然消除了1年。我们的发现表明，MP感染可能有助于通过长期废除Treg介导的抑制来增加患严重的过敏性疾病的风险。

项目成果

重症薬疹とレギュラトリーT細胞

严重药疹与调节性T细胞

• 发表时间: 2010
• 期刊: 臨床免疫・アレルギー科 54巻1号(投稿中)
• 作者: 天羽康之;Maho Kanoh;新山史朗;Yuko Hamada;Katsumasa Kawahara;Kensei Katsuoka;and Robert M. Hoffman;高橋良
• 通讯作者: 高橋良

Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions

• DOI: 10.1111/j.1365-2230.2010.03820.x
• 发表时间: 2010-12-01
• 期刊: CLINICAL AND EXPERIMENTAL DERMATOLOGY
• 影响因子: 4.1
• 作者: Hirahara, K.;Kano, Y.;Shiohara, T.
• 通讯作者: Shiohara, T.

マイコプラズマ感染はDIHS発症を抑制する

支原体感染抑制 DIHS 的发展

• 发表时间: 2011
• 作者: Uehara T.;Sumiyoshi T.;Seo T.;Matsuoka T.;Itoh H.;Suzuki M.;Kurachi M;水川良子
• 通讯作者: 水川良子

制御性T細胞と重症薬疹

调节性 T 细胞和严重药疹

• 发表时间: 2011
• 期刊: 日本皮膚科学会雑誌
• 作者: 石田正;高橋良;塩原哲夫
• 通讯作者: 塩原哲夫