Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

功能性精神病中大脑半球积分紊乱

• 批准号: 60304063
• 负责人: TAKAHASHI Ryo
• 金额: $ 7.04万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60304063/
• 关键词: Functional Psychoses; Integral Function of Cerebral Hemispheres; Neuropsychology; Eye Movements; Event-relsted Potential; CNV; Regional Blood Flow; MRI-CT; 脳局所血流; 核磁気共鳴脳断層撮影; 精神分裂病

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less

在功能性精神病中，脑半球的整体功能的干扰是为了阐明使用多维方法在功能性精神病中大脑半分类的差异和积分功能的灾难。使用神经生理学，心理生理学，神经心理学和形态学方法，探索了左右半球以及皮质和皮层下区域以及额叶和后部区域之间的关系。 H. Torii博士探索了精神分裂症的镜像写作和年龄分离，H。H. H. H. H.使用新的WISCONSIN卡片分类测试。显示了通过水平眼运动测得的功能性精神病的大脑横向化，Takahashi博士，r。检查了临床症状与通过眼动测量的临床症状之间的关系，他还研究了眼睛固定和移动的大脑横向化……与尖峰的焦点相比。 Niwa博士表明，精神分裂药物对精神分裂症的注意力和半球功能障碍的事件相关的潜在相关性。 Machiyama博士，Y。还研究了与事件相关的潜力，以阐明精神分裂症信息处理异常的地形和临时方面。 Yamaguchi博士，N。审查了精神分裂症患者和抑郁症患者的区域血流。 Inananaga，k。使用MRI-CT检查了精神分裂症患者大脑的形态变化。从左右半球功能的角度来看，我们的大多数研究表明，精神分裂症患者具有左半球功能障碍，而不是右半球功能障碍。神经生理学报告表明，根据偏执型和非偏个酸的精神分裂症的预后或类型，脑半球功能的主要方面发生了变化。尽管精神分裂症的低核心理论很普遍，但我们项目中获得的结果与该理论不一致，不仅建议额叶，而且建议其他区域（例如边缘系统），丘脑粘膜和基底神经神经节可能会涉及产生精神分裂症。这些协作研究已经完成了3 YESRD，这对于阐明精神分裂症的病理生理机制非常有益。较少的

项目成果

Yoshihiko Matsue;Teruo Okuma et al.: Biol Psychiatry. 21. 382-389 (1986)

Yoshihiko Matsue；Teruo Okuma 等：Biol Psychiatry。

Kashima, H.: "Disorders of attenticn due to grontal lobe lesion." Advances in Neurological Sciences. 30. 847-858 (1986)

Kashima, H.：“由于齿龈叶病变导致的注意力障碍。”

丹野義彦,町山幸輝: 臨床精神医学. 15. 53-62 (1986)

Yoshihiko Tanno，Yukiteru Machiyama：临床精神病学 15. 53-62 (1986)

鹿島 晴雄: 神経研究の進歩. 30. 847-858 (1986)

Haruo Kashima：神经学研究进展。30。847-858（1986）

Matsue, Y.: "Saccadic Eye Movements in Tracking,Fixation,and Rest in Schizophrenic and Nornal Subjects." 21. 382-389 (1986)

Matsue, Y.：“精神分裂症和正常受试者跟踪、注视和休息中的眼跳运动。”