A study about the condition of the female pattern hair loss throughandrogen receptor.

通过雄激素受体研究女性型脱发状况。

• 批准号: 22791082
• 负责人: NOMIYAMA Tomoko
• 金额: $ 2.33万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791082/
• 关键词: 男性型脱毛症; アンドロゲンレセプター; androgen receptor

We collected the skin tissue sample on the female scalp. We check the protein level of Androgen receptor (AR) by Western blot analysis. In the dermal papilla cells of the normal woman, the AR protein was recognized in all cases. However, the woman was very small amount of AR protein than the man. The imaging analysis of AR in the cells that using the primary culture dermal papilla cells. There were two types AR that one was to shift in the nucleus with the ligand and the other was not. This ratio was 1:2. By the cell proliferation assay , the proliferation suppressant effect of the dermal papilla cell by ligand did not accept it. In addition, the quantity of TGF-beta of the culture top liquid did not accept a difference before and after the ligand dosage. Than the dermal papilla cell of the woman scalp had AR, but this was more small amount than the thing of the man, and it was thought that sensitivity was different.

我们在女性头皮上收集了皮肤组织样品。我们通过Western印迹分析检查雄激素受体（AR）的蛋白质水平。在正常妇女的真皮乳头细胞中，在所有情况下都识别出AR蛋白。但是，女人比男人的AR蛋白很少。使用原发性皮肤乳头细胞的细胞中AR的成像分析。有两种类型的AR是用配体在细胞核中移动的，另一种不是。这个比率为1：2。通过细胞增殖分析，配体对真皮乳头细胞的增殖抑制作用不接受。另外，培养基液体的TGF-β量在配体剂量之前和之后不接受差异。女性头皮的真皮乳头细胞比男人的东西要少，但人们认为敏感性不同。

项目成果

Immunohistological analysis of in-transit metastasis in a patient with advanced melanoma treated with combination therapy of cytosine guanine dinucleotide oligodeoxynucleotide, dacarbazine and beta-interferon: A case report.

接受胞嘧啶鸟嘌呤二核苷酸寡脱氧核苷酸、达卡巴嗪和β-干扰素联合治疗的晚期黑色素瘤患者中途转移的免疫组织学分析：病例报告。

• DOI: 10.1111/j.1346-8138.2012.01517.x
• 发表时间: 2012
• 期刊: The Journal of Dermatology
• 作者: Akiko Ozawa;Tomoko Nomiyama;他5名
• 通讯作者: 他5名

先天性欠毛症の 1 例

先天性脱发一例

• 发表时间: 2012
• 作者: 野見山朋子;浅井純;竹中秀也;加藤則人
• 通讯作者: 加藤則人

先天性欠毛症の1例

先天性脱发一例

• 发表时间: 2012
• 作者: 野見山朋子;浅井純;竹中秀也;加藤則人
• 通讯作者: 加藤則人

Diffuse alopecia caused by iatrogenic failure of estrogen secretion in a patient with acute lymphocytic leukemia

急性淋巴细胞白血病医源性雌激素分泌障碍致弥漫性脱发

• 发表时间: 2010
• 作者: Tomoko Kitagawa;at.El
• 通讯作者: at.El

Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia : connection to Iatrogenic failure of estrogen secretion

急性淋巴细胞白血病治疗中多因素副作用引起的顽固性弥漫性脱发：与医源性雌激素分泌障碍的关系

• DOI: 10.1111/j.1525-1470.2011.01692.x
• 发表时间: 2011
• 期刊: Pediatric Dermatology
• 影响因子: 1.5
• 作者: Tomoko Nomiyama;at.El.
• 通讯作者: at.El.