Analysis of atopic dermatitis induced bycoenzyme A in mothers' milk, and its development for preventive medicine

母乳中辅酶A诱发特应性皮炎的分析及其预防医学的发展

• 批准号: 22790997
• 负责人: HIGASHI Takehiro
• 金额: $ 2.58万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790997/
• 关键词: アトピー性皮膚炎; Coenzyme A; 母乳; Th2アジュバント; 樹状細胞; coenzymeA; CoenzymeA

The current study showed that some mothers,whose children developed AD, carry high Th2 adjuvant activity in their milk. A low concentration of CoA exhibited Th2 adjuvant activity both in vitro andin vivo. Moreover, mesenteric lymph nodenon-T cells obtained from mice that were orally treated with CoA, led allogeneic naive CD4+T cells to differentiate into Th2. Furthermore, the oral administration of CoA induced atopic dermatitis in mice.

目前的研究表明，一些孩子患有 AD 的母亲的乳汁中含有较高的 Th2 佐剂活性。低浓度的 CoA 在体外和体内均表现出 Th2 佐剂活性。此外，从口服 CoA 治疗的小鼠中获得的肠系膜淋巴结非 T 细胞，导致同种异体幼稚 CD4+T 细胞分化为 Th2。此外，口服 CoA 会诱发小鼠特应性皮炎。

项目成果

Coenzyme A concentration in mother`s milk predicts the atopic dermatitis-inducing potential in a cohort of Japanese infants

母乳中的辅酶 A 浓度可预测一组日本婴儿诱发特应性皮炎的可能性

• 发表时间: 2010
• 作者: Higashi,T.;Shimojo;N.;Suzuki;S.;Nakaya;M.;Takagi;R.;Hashimoto;K.;Kohno;Y.;Matshishita;S
• 通讯作者: S

Coenzyme A concentration in mother's milk predicts the atopic dermatitis-inducing potential in a cohort of Japanese infants.

母乳中辅酶 A 的浓度可以预测一组日本婴儿诱发特应性皮炎的可能性。

• 发表时间: 2010
• 作者: Higashi;T.
• 通讯作者: T.

Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis

• DOI: 10.1093/intimm/dxr085
• 发表时间: 2011-12-01
• 期刊: INTERNATIONAL IMMUNOLOGY
• 影响因子: 4.4
• 作者: Higashi, Takehiro;Shimojo, Naoki;Matsushita, Sho
• 通讯作者: Matsushita, Sho

Dopamine D1-like receptor antagonist attenuates Th17-mediated immune response and OVA-Ag-induced neutrophilic airway inflammation

多巴胺 D1 样受体拮抗剂减弱 Th17 介导的免疫反应和 OVA-Ag 诱导的中性粒细胞气道炎症

• 发表时间: 2011
• 期刊: J.Immunol.
• 作者: Nakagome;K
• 通讯作者: K

Curdlan Induces DC-Mediated Th17 Polarization via Jagged1 Activation in Human Dendritic Cells

• DOI: 10.2332/allergolint.09-oa-0103
• 发表时间: 2010-06-01
• 期刊: Allergology International
• 影响因子: 6.8
• 作者: Higashi, Takehiro;Hashimoto, Kumiko;Matsushita, Sho
• 通讯作者: Matsushita, Sho