Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice

经皮免疫诱导小鼠抗原特异性粘膜和系统免疫反应

• 批准号: 22591911
• 负责人: MASEDA Yoshiko
• 金额: $ 2.83万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591911/
• 关键词: ホスホリルコリン; コレラトキシン; 経皮免疫; 経鼻免疫; 特異的IgA; ﾎｽﾎﾘﾙｺﾘﾝ; ｺﾚﾗﾄｷｼﾝ; 粘膜免疫応答; ワクチン; 舌下免疫; 特異的抗体価; Phoshorylcholine(PC)

In order to investigate the differences in the immune responsesamong several mucosal immunizations, mice were immunized with phosphorylcholine (PC) together with cholera toxin (CT) as mucosal adjuvant intranasally and transcutaneously, and the mucosal as well as systemic immune responses were compared. PC-specific IgA antibody titers in saliva and nasal wash were increased by intaranasal as well as transcutaneous immunization to the same levels.

为了探讨几种粘膜免疫免疫反应的差异，采用磷酸胆碱（PC）联合霍乱毒素（CT）作为粘膜佐剂经鼻和经皮免疫小鼠，比较粘膜和全身免疫反应。通过鼻内和经皮免疫，唾液和鼻洗液中的 PC 特异性 IgA 抗体滴度增加至相同水平。

项目成果

コレラトキシン経皮免疫による粘膜免疫応答

霍乱毒素透皮免疫引起的粘膜免疫反应

• 发表时间: 2013
• 作者: 北村 拓朗 ;宮崎 総一郎 ;鈴木 秀明;牧瀬高穂;Yuichi Kurono;永野広海;宮下圭一;Keiichi Miyashita;永野広海;永野広海;黒野祐一;永野広海
• 通讯作者: 永野広海

Intranasal immunization of with Phosphorylcholine reduced type Iallergic responses in mice. 24thCongrress of the European Rhinologic Society

磷酸胆碱的鼻内免疫减少了小鼠的类型过敏反应。

• 发表时间: 2012
• 作者: 石川征司;楯谷一郎;早坂孝宏;瀧澤義徳;大野 覚;児嶋 剛;木谷芳晴;北村守正;平野 滋;瀬藤光利;伊藤壽一;Yoshinori Matsuwaki;Y. Kurono
• 通讯作者: Y. Kurono

Transcutaneous immunization with cholera toxin in BALB/C mice.

BALB/C 小鼠霍乱毒素经皮免疫。

• 发表时间: 2012
• 作者: 石川征司;楯谷一郎;大野覚;児嶋剛;木谷芳晴;瀧澤義徳;早坂孝宏;北村守正;平野滋;瀬藤光利;伊藤壽一;山内一真;H. Nagano
• 通讯作者: H. Nagano

Immunological difference in upper respiratory tracts between sublingual and intranasal immunization

舌下和鼻内免疫上呼吸道免疫学差异

• 发表时间: 2011
• 作者: 山内一真;山中昇;永野広海;山内一真;Yoshiko Hayamizu
• 通讯作者: Yoshiko Hayamizu

Diversity of mucosal immune responses in upper respiratory airways and the suitability of mucosal vaccines

上呼吸道粘膜免疫反应的多样性和粘膜疫苗的适用性

• 发表时间: 2012
• 期刊: Clinical & Experimental Allergy Reviews
• 作者: Matsuwaki Y;Wada K;White T;Moriyama H;Kita H;Y. Kurono
• 通讯作者: Y. Kurono