Changes of developments of central auditory system following early hearing loss in animal experiment.

动物实验中早期听力损失后中枢听觉系统发育的变化。

• 批准号: 22591877
• 负责人: ITO Makoto
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591877/
• 关键词: 先天聾モデル; 聴覚中枢; 発達; 急性内耳障害; 脳の可塑性; アミノグリコシド; アミカシン

The purpose of this study was to investigate the effects of early hearing loss on the anatomy of the central auditory system, specifically, the ascending projections to the inferior colliculus (IC). We compared normal animals with animals deafened during early development by administration of amikacin, an ototoxic antibiotic that is known to destroy the hair cells in the inner ear. Neonatal deafness reduces the number of labeled neurons projecting from the CN to the IC with the effect being more evident during later stages of deafness. In contrast, there are no significant changes in the projections from DNLL to IC.

这项研究的目的是研究早期听力损失对中央听觉系统解剖结构的影响，特别是对下丘的升预测（IC）。我们通过给药amikacin（一种可消灭内耳中毛细胞的耳毒性抗生素，在早期发育过程中聋的动物比较了正常的动物。新生儿耳聋减少了从CN到IC投射的标记神经元的数量，在聋哑后期阶段更为明显。相反，从DNLL到IC的预测没有重大变化。

项目成果

Cochlear implantation in a patient with superficial siderosis

• DOI: 10.1016/j.anl.2011.10.009
• 发表时间: 2012-12-01
• 期刊: AURIS NASUS LARYNX
• 影响因子: 1.7
• 作者: Sugimoto, Hisashi;Ito, Makoto;Yoshizaki, Tomokazu
• 通讯作者: Yoshizaki, Tomokazu

Changes in projections to the inferior colliculus following early hearing loss in rats

• DOI: 10.1016/j.heares.2012.03.011
• 发表时间: 2012-05
• 期刊: Hearing Research
• 影响因子: 2.8
• 作者: M. Hatano;Makoto Ito;T. Yoshizaki;J. Kelly

Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Nasopharynx in Young Children Attending Day Care in Japan

日本日托幼儿鼻咽分离肺炎链球菌的血清型分布和青霉素耐药性

• 发表时间: 2011
• 作者: Ito M;Hatano M;Sugimoto H;Yoshizaki T
• 通讯作者: Yoshizaki T

Roles of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma of the Temporal Bone

• DOI: 10.1097/mao.0b013e31820d9654
• 发表时间: 2011-04
• 期刊: Otology & Neurotology
• 影响因子: 2.1
• 作者: H. Sugimoto;Makoto Ito;M. Hatano;S. Kondo;Shioto Suzuki;T. Yoshizaki

A case of chronic otitis media caused by Mycobacterium abscessus

脓肿分枝杆菌致慢性中耳炎1例

• 发表时间: 2010
• 期刊: Auris Nasus Larynx (In press)
• 作者: Sugimoto H;Ito M;Hatano M;Nakanishi Y;Maruyama Y;Yoshizaki T.
• 通讯作者: Yoshizaki T.