Activation of ER stress as the major molecular pathology in autism spectrum disorder and the animal model for intervention study

内质网应激的激活作为自闭症谱系障碍的主要分子病理学及干预研究的动物模型

• 批准号: 22591135
• 负责人: MOMOI Mariko
• 金额: $ 2.83万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591135/
• 关键词: 内科系臨床医学; 小児科学; 自閉性障害; CADM1; 自閉性障害関連遺伝子; ERストレス

We reported that the loss of Cadm1, one of the autism-related gene, caused decreased social ability, anxiety and aggression. The cells expressed mutated CADM1 protein showed the aberrant and aborted extension of neuronal spikes and the decreased synaptogenesis. We also detected that the mutated CADM1 expressing cells showed the activation of CHOP and beclin, that suggest the activation of ER stress in the cells.

我们报告称，Cadm1（自闭症相关基因之一）的缺失会导致社交能力下降、焦虑和攻击性。表达突变的 CADM1 蛋白的细胞显示出神经元尖峰的异常和中止延伸以及突触发生的减少。我们还检测到突变的CADM1表达细胞显示出CHOP和beclin的激活，这表明细胞中ER应激的激活。

项目成果

小児期の広汎性発達障害:遺伝子と環境

儿童普遍性发育障碍：基因和环境

• 作者: Nikaido K;Tachi N;Ohya K;Wada T;Tsutsumi H;金村英秋;桃井真里子
• 通讯作者: 桃井真里子

Autism spectrum disorder ; shared molecular pathology

自闭症谱系障碍；

• 发表时间: 2011
• 期刊: Medical Science Digest
• 作者: Endo T;Baba T;Sugio A;Morishita M;Takahashi M;Akashi Y;Ishioka S;Tachi N;Hanaie R;Momoi MY
• 通讯作者: Momoi MY

Impairment of social and emotional behaviors in Cadm1-knockout mice

• DOI: 10.1016/j.bbrc.2010.04.165
• 发表时间: 2010-06-04
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takayanagi, Yuki;Fujita, Eriko;Onaka, Tatsushi
• 通讯作者: Onaka, Tatsushi

Cadm1-expressing synapses on Purkinje cell dendrites are involved in mouse ultrasonic vocalization activity.

• DOI: 10.1371/journal.pone.0030151
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Fujita E;Tanabe Y;Imhof BA;Momoi MY;Momoi T
• 通讯作者: Momoi T