Type I interferon and regulatory T cells associated with autoantibody production

I 型干扰素和调节性 T 细胞与自身抗体产生相关

• 批准号: 22591091
• 负责人: FUJII Takao
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591091/
• 关键词: タイプIインターフェロン; 抗核抗体; 全身性エリテマトーデス; タイプI インターフェロン; 肺高血圧症; 血管内皮細胞; 中枢神経ループス; ケモカイン; インターフェロン-α; インターフェロン-β; 肺血管内皮細胞; 肺微小血管内皮細胞

In the present study, I focused on neuropsychiatric systemic lupus erythematosus (NPSLE) and pulmonary arterial hypertension (PAH), which are associated with anti-U1 ribonucleoprotein antibodies (anti-U1RNP Abs). Type I IFN (IFN-α/β) could stimulates pulmonary arterial endothelial cells to secrete fractalkine and RANTES, that was suppressed by JAK inhibitors. In NPSLE, the presence of anti-U1RNP Abs in cerebrospinal fluid (CSF) was associated with high levels of IFN-α and MCP-1.

在本研究中，我重点关注神经精神系统性红斑狼疮 (NPSLE) 和肺动脉高压 (PAH)，它们与抗 U1 核糖核蛋白抗体（抗 U1RNP Abs）相关。刺激肺动脉内皮细胞分泌 fractalkine 和 RANTES，这在 NPSLE 中被 JAK 抑制剂抑制。脑脊液 (CSF) 中的抗 U1RNP 抗体与高水平的 IFN-α 和 MCP-1 相关。

项目成果

The RIG-I-like receptor IFIHI/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.

RIG-I 样受体 IFIHI/MDA5 是抗 CADM-140 抗体识别的皮肌炎特异性自身抗原。

• 发表时间: 2010
• 期刊: Rheumatology
• 影响因子: 5.5
• 作者: Nakashima R;Fujii;T;et al.
• 通讯作者: et al.

Serum BAFF and APRIL levels in patients with IgG4-related disease and their clinical significance.

• DOI: 10.1186/ar3810
• 发表时间: 2012-04-24
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Kiyama K;Kawabata D;Hosono Y;Kitagori K;Yukawa N;Yoshifuji H;Omura K;Fujii T;Mimori T
• 通讯作者: Mimori T

Intereferon-gamma release assay for diagnosing Mycobacterium tuberculosis infections in patients with systemic lupus eryt hematosus

干扰素-γ释放试验诊断系统性红斑狼疮患者结核分枝杆菌感染

• 发表时间: 2011
• 期刊: Lupus
• 影响因子: 2.6
• 作者: Takeda N;Fujii T;et al
• 通讯作者: et al

CORRELATION OF ANTINUCLEAR ANTIBODIES AND ANTI-DNA ANTIBODIES WITH CLINICAL RESPONSE TO INFLIXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS

类风湿性关节炎患者中抗核抗体和抗 DNA 抗体与英夫利昔单抗临床反应的相关性

• 发表时间: 2010
• 作者: N.Yukawa;T.Fujii;D.Kawabata;T.Nojima;K.Ohmura;T.Usui;T.Mimori
• 通讯作者: T.Mimori

Association between autoantibodies and inflammatory mediators in cerebrospinal fluids from patients with neiropsychiatric sustemic lupus erythematosus

神经精神性持续性红斑狼疮患者脑脊液中自身抗体与炎症介质的关联

• 发表时间: 2012
• 作者: Suka M. Hayashi T.;Kobayashi S.;Ito S.;Yumura W.;Ozaki S;Takao Fujii
• 通讯作者: Takao Fujii