Effect of acupuncture on the molecular mechanism of inflammation via transcription factor, NFkB.

针灸通过转录因子 NFkB 对炎症分子机制的影响。

• 批准号: 22590670
• 负责人: MATSUKUMA Hideaki
• 金额: $ 2.75万
• 依托单位: Morinomiya University of Medical Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590670/
• 关键词: 東洋医療; 鍼灸刺激; 炎症性腸疾患; 筋肉再生; 創傷治癒; 炎症性サイトカイン; マクロファージ; 内科学一般; 東洋医学; 炎症; 転写因子; NFkB; サイトカイン

Recently, there has been a focus on a variety of complementary and alternative medicine in the field of health care. However, the effect of acupuncture is still unclear. In this study we investigated the effect of acupuncture and moxibustion on molecular mechanisms of inflammation. Procedure of acupuncture into normal skin resulted in no effect on local inflammation. However, our data demonstrated that electro-acupuncture supressed disease activity and colonic inflammation in DSS-induced colitis through a reduction in propagated colonic peristalsis mediated by sympathetic over-activity, suggesting the potential of acupuncture as a relief therapy for inflammatory bowel disease. On the other hand, moxibustion accelerated muscle regeneration and promoted wound healing through induction of inflammation.

最近，医疗保健领域的各种补充和替代医学受到关注。然而，针灸的效果仍不清楚。在这项研究中，我们研究了针灸对炎症分子机制的影响。针刺正常皮肤的过程对局部炎症没有影响。然而，我们的数据表明，电针通过减少交感神经过度活动介导的结肠蠕动来抑制 DSS 诱导的结肠炎的疾病活动和结肠炎症，这表明针灸作为炎症性肠病缓解疗法的潜力。另一方面，艾灸通过诱导炎症加速肌肉再生并促进伤口愈合。

项目成果

腸炎モデルマウスに対する鍼刺激の影響-炎症性腸疾患への補完医療確立に向けて-

针刺刺激对肠炎模型小鼠的影响-建立炎症性肠病的补充药物-

• 发表时间: 2013
• 作者: 湯谷達;川畑浩久;青木元邦
• 通讯作者: 青木元邦

Anti-inflammatory effect of electro-acupuncture via rduction in clonic pristalsis in a mouse model of inflammatory bowel disease.

电针通过减少炎症性肠病小鼠模型中阵挛性蠕动的抗炎作用。

• DOI: 10.2174/1871522211313020006
• 发表时间: 2013
• 期刊: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry.
• 作者: Yutani T;Kawahata H;Sotobayashi D;Kawanami H;Matsukuma H;Aoki M.
• 通讯作者: Aoki M.

腸炎モデルマウスに対する鍼刺激の影響－炎症性腸疾患への補完医療確立に向けて－

针刺刺激对肠炎模型小鼠的影响-建立炎症性肠病的补充药物-

• 发表时间: 2012
• 作者: 湯谷達;川畑浩久;青木元邦;青木元邦
• 通讯作者: 青木元邦