Study on the evaluation of new biomarker's predictability of the onset of atherothrombosis

新生物标志物对动脉粥样硬化血栓形成预测能力的评价研究

基本信息

批准号：
22590601
负责人：
SAKATA Kiyomi
金额：
$ 3.08万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.

测量了最初的随访，其最初的随访时间是6年前，测量了S100A12蛋白的血清水平和完成成分C3A的分解产物，并与基线结果进行了比较。Spearman与S100A12和C3A之间的血清浓度相关的核心与C3A和C3A之间的血清相关性。 S100A12浓度与甘油三酸酯水平以及白细胞计数的相关系数很重要。 C3A分解产物与HDL胆固醇水平，白细胞计数，血糖水平，HBALC，收缩压，舒张压和体重指数的分解产物浓度的相关系数也很重要。现有状况和事件中风与S100A12或C3A都没有显着关联。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Comparison of low-density lipoprotein cholesterol concentrations measured by a direct homogeneous assay and by the Friedewald formula in a large community population

DOI：
10.1016/j.cca.2010.07.034
发表时间：
2010-11-11
期刊：
CLINICA CHIMICA ACTA
影响因子：
5
作者：
Tanno, Kozo;Okamura, Tomonori;Okayama, Akira
通讯作者：
Okayama, Akira

Plasma B-Type Natriuretic Peptide is Useful for Cardiovascular Risk Assessment in Community-Based Diabetes Subjects -Comparison with Albuminuria.

血浆 B 型利钠肽可用于社区糖尿病受试者的心血管风险评估 - 与蛋白尿比较。

DOI：
发表时间：
2012
期刊：
International Heart Journal
影响因子：
1.5
作者：
Onodera M;Nakamura M;Tanaka F;Takahashi T;Makita S;Ishisone T;Ishibashi Y;Itai K;Onoda T;Ohsawa M;Tanno K;Sakata K;Omama S;Ogasawara K;Ogawa A;Kuribayashi T;Sakamaki K;Okayama A.
通讯作者：
Okayama A.

東日本大震災被災者健診からみた被災者の健康リスクと循環器疾患罹患状況

从体检看东日本大地震受害者的健康风险和心血管疾病患病率