A study on the relation of shift work on hormonal change and diseases of prostate

轮班工作对激素变化与前列腺疾病关系的研究

• 批准号: 22590557
• 负责人: MORIKAWA Yuko
• 金额: $ 2.75万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590557/
• 关键词: 産業衛生; 夜勤交代勤務; がん; 前立腺がん; PSA; 8OHデオキシグアノシン; 交代勤務; 深夜勤務; ハイドロキシデオキシグアノシン; 前立腺疾患; 罹患

We investigated the effects of night and shift work on cancer risk using serum prostatic specific antigen(PSA) and urinary 8-hydroxydeoxyguanosine (8-OHdG) as markers of cancer risk. However, we could not get the positive relationship between night and shift work and cancer risk. The study population consisted of 702 male employees aged 50-66 years in a factory in Japan. PSA level rose with increasing age, but not related with occupational factors including work schedule. The urinary8-OHdG level was the highest among the subjects engaged shift work without midnight shift, but statistically not significant.

我们使用血清前列腺特异性抗原 (PSA) 和尿液 8-羟基脱氧鸟苷 (8-OHdG) 作为癌症风险标记物，研究了夜间和轮班工作对癌症风险的影响。然而，我们无法得出夜班和轮班工作与癌症风险之间的正相关关系。研究对象包括日本一家工厂的 702 名年龄在 50-66 岁之间的男性员工。 PSA水平随着年龄的增长而升高，但与工作时间等职业因素无关。轮班无夜班的受试者尿8-OHdG水平最高，但无统计学意义。