Investigation of Indonesian Marine Organisms as Medicinal Resources

印度尼西亚海洋生物作为药用资源的调查

基本信息

批准号：
15406005
负责人：
KOBAYASHI Motomasa
金额：
$ 8.32万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15406005/
关键词：
Indonesia marine invertebrate medicinal resource marine sponge bioactivity

项目摘要

Indonesia consists of more than 17,000 islands distributed along the equator stretched over the two oceans. The Indonesian waters are known to have diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. This situation is not confined only to Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakarta and other coastal cities. The problem is serious not only from the viewpoint of environmental conservation.Considering these situations, we started the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters. The present research is carried out as a collaborative project of Pusat Penelitian dan Pengembangan Oseanologi (Research and Development Centre for Oceanology)-LIPI, Lampung University, Diponegoro University, Indonesia and Osaka University and University of the Ryukyus, Japan. We have proceeded survey of marine invertebrates at Lampung in Sumatra Island in 2003, Carita in Java Island in 2004, and Biak Island in 2005 as shown below. 1) Search for diversity and correction of marine invertebrates by SCUBA diving. 2) Isolation of bioactive constituents from those marine invertebrates. We have already isolated several anti-tumor active constituents (cell cycle inhibitor or anti-angiogenesis). 3) Separation of marine microorganism from marine sediment and investigation of bioactive constituents of those marine microorganisms.

印度尼西亚由 17,000 多个岛屿组成，分布在赤道沿岸，横跨两大洋。众所周知，印度尼西亚水域有多种固着生物，例如海绵和软珊瑚。然而，它们的区域和生物分布以及生物医学潜力却鲜为人知。我们是一群来自印度尼西亚和日本的科学家，旨在对这些生物体进行调查、收集以及化学和药物研究。由于工业和城市污水以及土地开发排放的红粘土沉积造成海岸环境恶化，日本海岸固着海洋生物的生存受到威胁。这种情况不仅限于日本。类似的情况也在印度尼西亚发生，特别是雅加达沿海和其他沿海城市。这个问题不仅从环境保护的角度来看很严重。考虑到这些情况，我们在印度尼西亚海洋生物中的一些物种从沿海水域消失之前开始了对作为新药先导化合物来源的印度尼西亚海洋生物的研究。本研究是 Pusat Penelitian dan Pengembangan Oseanologi（海洋学研究与发展中心）-LIPI、楠榜大学、印度尼西亚 Diponegoro 大学、日本大阪大学和琉球大学的合作项目。我们于2003年在苏门答腊岛的楠榜、2004年在爪哇岛的卡丽塔和2005年在比亚克岛进行了海洋无脊椎动物调查，如下所示。 1）通过水肺潜水寻找海洋无脊椎动物的多样性和校正。 2）从海洋无脊椎动物中分离生物活性成分。我们已经分离出几种抗肿瘤活性成分（细胞周期抑制剂或抗血管生成）。 3）从海洋沉积物中分离海洋微生物并研究这些海洋微生物的生物活性成分。