Search for Indonesian Marine Life as Medicinal Resource (2)

寻找印度尼西亚海洋生物作为药用资源 (2)

• 批准号: 11691208
• 负责人: KOBAYASHI Motomasa
• 金额: $ 15.02万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11691208/
• 关键词: Indonesia; Marine Invertebrate; Marine resource; Marine sponge; Biological active

The sea will continue to play important roles for the future of human being not only as the source of food and energy but also for the conservation of environment. Other than these roles, the sea is also expected to provide biologically active substances, which have potential to be developed into new medicines. Owing to the deterioration of coastal environment caused by industrial and municipal effluents and also by sedimentation of red clay discharged from land development, existence of sessile marine organisms are endangered in the coasts of Japan. Similar situation is developing in Indonesia, especially along the coasts of Jakkarta and other coastal cities. Considering these situations, it is important to initiate the study of Indonesian marine organisms as sources of lead compounds for new medicines before some of these species disappear from the coastal waters.The present research is carried out by the project in collaboration with Pusat Penelitian dan Pengembangan Oseanologi (Res … More earch and Development Center for Oceanology)- LIPI, Indonesia and Osaka University and University of the Ryukyus, Japan. The objectives of this proposal are to conduct a joint research on medicinal potential of Indonesian marine organisms and to promote scientific exchange between Indonesia and Japan in the disciplines encompassing marine biology, natural product chemistry, and biomedical science. The Indonesian waters are known to be rich in diverse species of sessile organisms such as sponges and soft corals. However, their regional and biological distribution and biomedical potential are scarcely understood. We, a group of scientists from both Indonesia and Japan, aim to conduct survey, collection, and chemical and pharmaceutical investigation of these organisms.The survey was proceeded at the coral reef of bitung, North Sulawesi, in August, 1999, the coral reef Kendari, South Sulawesi in August, 2000, and the coral reef of Labuanbajo, Flores Island in August, 2001. Mainly sessile invertebrates such as sponges and tunicate were surveyed and collected by scuba diving. The extracts of collecting samples were subjected to the screening bioassays (e. g. antimicrobial activity, cytotoxic activity against cultured tumor cells (KB, L1210), reversal activity of multi-drug resistance in tumor cell (KV-C2, KV-CV60, and KB-3-1 cell lines), and other viological activities. Less

海洋将继续为人类的未来发挥重要作用，不仅作为食物和能源的来源，而且对于保护环境，海洋还有望提供具有潜力的生物活性物质。由于工业和城市污水以及土地开发排放的红粘土沉积造成沿海环境恶化，日本沿海的固着海洋生物的存在也受到威胁。印度尼西亚，特别是雅加达沿岸和其他沿海城市，在其中一些物种从沿海水域消失之前，启动对印度尼西亚海洋生物作为新药物先导化合物来源的研究非常重要。该项目与印度尼西亚 LIPI 的 Pusat Penelitian dan Pengembangan Oseanologi（海洋学研究与发展中心）以及日本大阪大学和琉球大学合作开展。该提案的目的是对印度尼西亚海洋生物的药用潜力进行联合研究，并促进印度尼西亚和日本在海洋生物学、天然产物化学和生物医学科学等学科领域的科学交流。然而，我们，来自印度尼西亚和日本的科学家小组，旨在对海绵和软珊瑚等固着生物物种进行调查、收集以及化学和药物研究。这些生物体。 1999年8月在北苏拉威西岛bitung珊瑚礁、2000年8月在南苏拉威西岛Kendari珊瑚礁和2001年8月在弗洛勒斯岛Labuanbajo珊瑚礁进行了调查。主要是海绵等固着无脊椎动物通过水肺潜水对被囊类动物进行调查和采集，对采集样品的提取物进行筛选生物测定。 （例如抗菌活性、针对培养肿瘤细胞（KB、L1210）的细胞毒活性、肿瘤细胞（KV-C2、KV-CV60 和 KB-3-1 细胞系）多药耐药性的逆转活性以及其他生物活性。较少的

项目成果

S.Aoki: "Novel neuronal nitric synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta"Chem. Pharm. Bull.. 49. 1372-1374 (2001)

S.Aoki：“新型神经元一氧化氮合酶 (nNOS) 选择性抑制剂，海兔素型吲哚生物碱，来自海洋海绵 Hyrtiosecta”Chem.

S.Aoki: "Molecular modeling of 5-deacetylaltohyrtin A, a spogean cytotoxic"Tetrahedron. 57. 2289-2292 (2001)

S.Aoki：“5-脱乙酰基醛酸 A 的分子建模，一种 spogean 细胞毒性”四面体。

M.Murakami: "Total synthesis of Iembehyne A, a neuritogenic spongean polyacetylene"Tetrahedron Lett.. 41. 1941-1943 (2001)

M.Murakami：“Iembehyne A（一种神经源性海绵聚乙炔）的全合成”Tetrahedron Lett.. 41. 1941-1943 (2001)

M. Kobayashi, I. Kitagawa: "Marine spongean cytotoxins"J. Nat Toxins. 8. 249-258 (1999)

M. Kobayashi，I. Kitakawa：“海洋海绵动物细胞毒素”J。

M.Doi, T. Ishida, M. kobayashi, J. R. Dechamps and J. L. Flippen-Anderson: "The highly solvated structure of theonellapeptlide Id, a tridecapeptide lactone from the Okinawan marine sponge Theanella swinhoei"Acta Cryst.. C55. 796-798 (1999)

M.Doi、T. Ishida、M. kobayashi、J. R. Dechamps 和 J. L. Flippen-Anderson：“theonellapeptlide Id 的高度溶剂化结构，一种来自冲绳海洋海绵 Theanella swinhoei 的十三肽内酯”Acta Cryst.. C55。