Sudden coronary death, pokkuri disease, and lipoprotein-associated sphingosine 1-phosphate

冠心病猝死、pokkuri 病和脂蛋白相关 1-磷酸鞘氨醇

基本信息

批准号：
22590517
负责人：
NAKAJIMA Katsuyuki
金额：
$ 2.91万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590517/
关键词：
スフィンゴシン 1-リン酸ポックリ病レムナント心臓性突然死スフィンゴシン1-リン酸リポタンパク二次元マップ apoM apoA-I スフィンゴシン1-リン酸(S-1-P)レムナントリポ蛋白質 2次元電気泳動マップ S1P受容体

项目摘要

We have proposed that triglyceride-rich lipoprotein remnants are associated with the risk of sudden coronary death in younger cases without coronary atherosclerosis. However, it remains unclear how remnants are involved in coronary sudden death. In the present study, we tried to relate sphingosine1-phosphate (S1P), which is concentrated in lipoproteins, and apolipoprotein M, an S1P binding apolipoprotein, to sudden death. Our new assay method to detect S1P allowed to measure a low concentration of S1P in serum; however, there are any significant difference in S1P levels between normal and sudden death patients. We are now focusing on the difference in two dimensionalelectrophoresis pattern measured by anti-apoA-I and anti-apoM antidodies.

我们已经提出，富含甘油三酸酯的脂蛋白残留物与未经冠状动脉粥样硬化的年轻病例中突然冠状动脉死亡的风险有关。但是，尚不清楚残留物如何涉及冠状动脉猝死。在本研究中，我们试图将集中在脂蛋白中的辛基辛（S1P）和S1P结合载脂蛋白的载脂蛋白M与猝死相关。我们检测S1P的新测定方法允许测量血清中低浓度的S1P。但是，正常和猝死患者之间的S1P水平有任何显着差异。现在，我们关注的是通过抗Apoa-I和抗APOM抗动物测量的二维电泳模式的差异。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Non-HDL Cholesterol Shows Improved Accuracy for Cardiovascular Risk Score Classification Compared to Direct or Calculated LDL Cholesterol in a Dyslipidemic Population

DOI：
10.1373/clinchem.2010.154773
发表时间：
2011-03-01
期刊：
CLINICAL CHEMISTRY
影响因子：
9.3
作者：
van Deventer, Hendrick E.;Miller, W. Greg;Remaley, Alan T.
通讯作者：
Remaley, Alan T.

Remnant lipoproteins are a stronger risk factor for cardiovascular events than LDL-C from the studies of autopsies in sudden cardiac death cases.Recent Advances in Cardiovascular Risk Factors

根据对心源性猝死病例尸检的研究，残余脂蛋白是比 LDL-C 更强的心血管事件危险因素。心血管危险因素的最新进展

DOI：
发表时间：
2012
期刊：
Ed by Mehnaz Atiq. (Intech)
影响因子：
0
作者：
Nakajima K;Nakano T;Tokita Y;Nagamine T;Yatsuzuka S;Shimomura Y;Tanaka A;Sumino H;Nara M;Machida T;Murakami M.;Nakajima K and Fujita MQ.
通讯作者：
Nakajima K and Fujita MQ.

Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia