International Study of Pokkuri Death Syndrome II-Relationship with Brugada syndrome

Pokkuri 死亡综合症 II 与 Brugada 综合症关系的国际研究

• 批准号: 20406020
• 负责人: FUJITA MasakiQ.
• 金额: $ 10.82万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20406020/
• 关键词: ポックリ病; Lai-Tai; 突然死; 冠動脈攣縮; 動脈硬化; 不整脈; Brugada症; 脂質代謝

Pokkuri Death Syndrome (PDS) is a sudden unexpected nocturnal death of unknown cause which is known in Japan and other South-Asian countries. We analyzed the autopsy and the background data of sudden death cases in Thailand and identified that such death called Lai-Tai has the same features as PDS in Japan. Lipid analysis of Lai-Tai showed similar tendency as PDS. Genetic analysis of our PDS cases in Japan has shown the possibilities that some cases have the mutation in Brugada syndrome responsible gene, SC5NA.

Pokkuri死亡综合症（PDS）是一个突然的未知原因夜间夜间死亡，这在日本和其他南亚国家中闻名。我们分析了泰国猝死病例的尸检和背景数据，并确定称为Lai-tai的死亡具有与日本PDS相同的特征。 LAI-TAI的脂质分析显示出与PDS相似的趋势。对日本PDS病例的遗传分析表明，某些病例在Brugada综合征造成的基因SC5NA中具有突变。

项目成果

Fujita, MQ, Nakajima K, Takeichi S. Pokkuri Death Syndrome. Special Lecture at Dept.of Forensic Medicine, School of Medicine, Chulalongkorn University (Bangkok, Thailand, 2008. 10. 30)

Fujita，MQ，Nakajima K，Takeichi S. Pokkuri 死亡综合症。

Characteristics of apoB48 and apoB100 carrying remnant lipoproteins (RLP) in postprandial plasma.

餐后血浆中携带残余脂蛋白（RLP）的apoB48和apoB100的特征。

• 发表时间: 2010
• 作者: Kentaro Nakamoto;et al.;林登志雄,余澤雲,井口昭久;Nakajima K
• 通讯作者: Nakajima K

Characteristics of apoB-48 and apoB-100 carrying remnant lipoproteins (RLP) in postprandial plasma.

餐后血浆中携带残余脂蛋白（RLP）的apoB-48和apoB-100的特征。

• 发表时间: 2009
• 作者: 柴田英治;Mo'men Hafez;市原学;市原佐保子;上島通弘;酒井潔;K.Nakajima
• 通讯作者: K.Nakajima

Detection of apoiipoproteins B-48 and B-100carrying particles in lipoprotein fractions extracted from human aortic atherosclerotic plaques in sudden cardiac death cases.

心源性猝死病例中从人主动脉粥样硬化斑块中提取的脂蛋白组分中检测载脂蛋白 B-48 和 B-100 携带颗粒。

• 发表时间: 2008
• 期刊: Clin Chim Acta 390
• 作者: Nakano T;et al.
• 通讯作者: et al.

Fujita, MQ, Nakajima K, Takeichi S. Pokkuri Death Syndrome. Update in Forensic Pathology (jointly organized by UiTM and Ministry of Health). Faculty of Medicine, Universiti Teknologi MARA(UiTM) (Shah Aalm, Malaysia, 2009. 9. 8)

Fujita，MQ，Nakajima K，Takeichi S. Pokkuri 死亡综合症。