Effect on hepatic fibrosis of omega-3 fatty acids and their lipid mediators.

omega-3 脂肪酸及其脂质介质对肝纤维化的影响。

• 批准号: 22500768
• 负责人: KAWAKAMI Takayo
• 金额: $ 2.58万
• 依托单位: Okayama Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500768/
• 关键词: 慢性肝疾患; オメガ3脂肪酸; 肝線維化; 生理活性脂質

We studied on progression of nonalcoholic Fatty liver disease (NAFLD) focus on anti-inflammatory and anti-fibrotic effect of omega3 fatty acid mediators. We showed that NAS (NAFLD activity score) in NASH model mice fed with EPA oil was significantly lower than control mice. Further, we observed that the addition of resolvins or their precursors to hepatic stellate cell cause reduction of the cellular collagen concentration. These results may derive from inhibition of production or degradation of collagen in HSC. We also investigated the serum CK18 level and its correlation with nutritional parameters in middle-aged Japanese males with NAFLD. We showed that members of the NAFLD group showed higher levels of serum CK18 levels and strongly associated with serum ALT and plasma DGLA. Abnormal fatty acid metabolism may be a factor of aggravation in NAFLD. Further examination including mechanism of omega3 fatty acid mediators on chronic liver disease should be performed.

我们研究了非酒精性脂肪肝病的进展（NAFLD），重点是欧米茄脂肪酸介质的抗炎和抗纤维化作用。我们表明，用EPA油喂养的NASH模型小鼠中的NAS（NAFLD活性评分）明显低于对照小鼠。此外，我们观察到，在肝星状细胞中添加溶胶蛋白或它们的前体导致细胞胶原蛋白浓度的降低。这些结果可能来自HSC中胶原蛋白的生产或降解的抑制。我们还研究了血清CK18水平及其与NAFLD中年男性中的营养参数的相关性。我们表明，NAFLD组的成员显示出更高水平的血清CK18水平，并且与血清ALT和血浆DGLA密切相关。异常的脂肪酸代谢可能是NAFLD加重的因素。应进一步检查包括在慢性肝病上的omega3脂肪酸介质机制。

项目成果

慢性肝疾患の病態栄養とその管理

慢性肝病的营养营养及其治疗

• 发表时间: 2012
• 期刊: 成人病と生活習慣病
• 作者: 長井宏樹;林久由;鈴木裕一;Hayashi H;住田 実;岡本秀己;冨岡加代子,田淵真愉美,川上貴代
• 通讯作者: 冨岡加代子,田淵真愉美,川上貴代

健診における脂肪肝の性差に関する検討

健康体检中脂肪肝的性别差异研究

• 发表时间: 2010
• 作者: 田淵真愉美,川上貴代,冨岡加代子

川上貴代 脂肪肝を防いで肝心要の肝臓守ろう,山陽新聞生き生き栄養楽,2012年7月21日,山陽新聞夕刊

川上隆世 预防脂肪肝，保护重要肝脏，山阳新闻活力营养，2012年7月21日，山阳新闻晚报版

Trial Implementation of Objective structured clinical examination at the dietary education seminar of resisterd dietitian training course.

抵抗营养师培训课程膳食教育研讨会试行客观结构化临床考试

• 作者: Y. Minamiyama;S. Takemura;S. Taketani;Y. Naito;H. Ichikawa,T. Takagi;S. Okada;and T. Yoshikawa;田淵真愉美;平本福子;市川実久,井上広子,桑野稔子;Sato K
• 通讯作者: Sato K

Trans-fatty Acid Compositions of Serum Phospholipids in Middle-aged Japanese Males

日本中年男性血清磷脂的反式脂肪酸组成

• 发表时间: 2011
• 作者: K. Tomioka;M. Tabuchi;Y. Murakami;T. Kawakami;N. Nakajima;M. Okita
• 通讯作者: M. Okita