Studies for the functional difference of STX1A and STX1B in vivo

STX1A和STX1B体内功能差异的研究

• 批准号: 22500338
• 负责人: FUJIWARA Tomonori
• 金额: $ 2.66万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500338/
• 关键词: シナプス伝達; シンタキシン; 痙攣; 遺伝子欠損マウス; 遺伝子改変マウス; 行動異常; 開口放出; syntaxin; 遺伝子組み換えマウス; シナプス; SNARE蛋白質

In neurons, two types of syntaxin (STX) isoforms, STX1A and STX1B,were expressed. It was believed that STX1A and STX1B have same function. However, we demonstrated that these proteins exhibited distinctive function in vivo. We showed the difference of the interaction with one of the STX binding proteins, Munc18, which might cause for the functional differences.

在神经元中，表达了两种类型的语法（STX）同工型，STX1A和STX1B。人们认为STX1A和STX1B具有相同的功能。但是，我们证明了这些蛋白质在体内表现出独特的功能。我们显示了与一种与STX结合蛋白之一Munc18相互作用的差异，这可能导致功能差异。

项目成果

Diminishment of the cortical signal propagation in HPC-1 / syntaxin 1A knockout mice

HPC-1 / Syntaxin 1A 敲除小鼠中皮质信号传播的减少

• 发表时间: 2012
• 作者: M Osanai;A Matsumura;T Fujiwara;I Mori;K Akagawa;T Yagi
• 通讯作者: T Yagi

A study on the neuronal phenotype of syntaxin1B knockout mice: implication of differential role of syntaxin1A and syntaxin1B in synaptic transmission

Syntaxin1B 敲除小鼠神经表型的研究：Syntaxin1A 和 Syntaxin1B 在突触传递中的差异作用的意义

• 发表时间: 2011
• 作者: T Mishima;T Fujiwara;M Sanada;T Kofuji;K Akagawa
• 通讯作者: K Akagawa

Analyses of insulin-granule docking and fusion in Granuphilin- and/or Syntaxin-1aknockout mice

Granuphilin 和/或 Syntaxin-1 敲除小鼠中胰岛素颗粒对接和融合的分析

• 发表时间: 2011
• 作者: R Ishizaki;H Wang;T Fujiwara;K Akagawa;and T Izumi
• 通讯作者: and T Izumi

Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CA1 Synapses in HPC-1/Syntaxin 1A Knock-out MiceJ

HPC-1/Syntaxin 1A 敲除小鼠海马 CA1 突触长期增强过程中儿茶酚胺系统的损伤 J

• 发表时间: 2012
• 期刊: Neurosci
• 作者: Sasaki Y.;Xing L.;Gross C.;Goshima;Y.;Bassell G.J.;T Mishima T Fujiwara T Kofuji and K Akagawa
• 通讯作者: T Mishima T Fujiwara T Kofuji and K Akagawa

A study on the phenotype of syntaxin1B knockout mice

Syntaxin1B基因敲除小鼠表型研究

• 发表时间: 2010
• 作者: T Fujiwara;M Sanada;T Kofuji;T Mishima and K Akagawa
• 通讯作者: T Mishima and K Akagawa