Clinicopathological study of central nervous system rhabdoid tumors with or without INI1 protein expression

伴或不伴INI1蛋白表达的中枢神经系统横纹肌样肿瘤的临床病理学研究

• 批准号: 22500319
• 负责人: HIRATO Junko
• 金额: $ 2.25万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500319/
• 关键词: ラブドイド腫瘍; INI1 蛋白; ラブドイド細胞; グリオーマ; epithelioid/rhabdoid cell; composite rhabdoid tumor; array CGH; brain tumor; rhabdoid tumor; INI1; epithelioid glioblastoma; rhabdoid glioblastoma; AT/RT; BRG1; INI1蛋白; 非定型奇形腫様ラブドイド腫瘍; rhabdoid cell; epit

Central nervous system rhabdoid tumors(CNS RTs) were divided into INI1 protein-negative and -positive groups. All INI1-negative RTs were consistent with atypical teratoid rhabdoid tumor (AT/RT) in the histopathological features. Moreover, there were a few cases with combined tumors composed of INI1-positive glioma and INI1-negative rhabdoid tumors. In the INI1-positive RTs, high-grade gliomas with epithelioid/rhabdoid cells were identified, and the presence of INI1-positive AT/RT was possibly considered.

中枢神经系统横纹肌样瘤（CNS RT）分为INI1蛋白阴性组和INI1蛋白阳性组。所有INI1阴性RT的组织病理学特征均与非典型畸胎瘤样横纹肌样瘤（AT/RT）一致。此外，还有少数病例为INI1阳性胶质瘤和INI1阴性横纹肌样瘤组成的复合肿瘤。在 INI1 阳性 RT 中，鉴定出具有上皮样/横纹肌样细胞的高级胶质瘤，并且可能考虑 INI1 阳性 AT/RT 的存在。

项目成果

Rhabdoid featureを示す神経上皮性腫瘍

显示横纹肌样特征的神经上皮肿瘤

• 发表时间: 2012
• 期刊: 病理と臨床
• 作者: 高橋亜紀代;平井志伸;丸山千秋;三輪昭子;岡戸晴生;平戸純子
• 通讯作者: 平戸純子

Rhabdoid tumor

横纹肌样瘤

• 发表时间: 2010
• 期刊: 病理と臨床
• 作者: Fujimoto Y;Hirato J;Wakayama A;Yoshimine T.;石龍徳;平戸純子;Seki T;平戸純子
• 通讯作者: 平戸純子

Atypical teratoid/rhabdoid tumorの病理

非典型畸胎瘤样/横纹肌样瘤病理学

• 作者: She-Qing Zhang;Darrell Sawmiller;Song Li;Kavon Rezai-Zadeh;Huayan Hou;Shufeng Zhou;Douglas Shytle;Brian Giunta;Frank Fernandez;Takashi Mori;Jun Tan;平戸純子
• 通讯作者: 平戸純子

Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult

成人枕叶复合性高级别胶质瘤和横纹肌样瘤的横纹肌样成分快速进展

• DOI: 10.1007/s10014-011-0069-6
• 发表时间: 2012
• 期刊: Brain Tumor Pathol
• 影响因子: 3.3
• 作者: Yamamoto J;Takahashi M;Nakano Y;Soejima Y;Saito T;Akiba D;Hirato J;Nakazato Y;Nishizawa S.
• 通讯作者: Nishizawa S.

large congenital melanocytic nevi with atypical teratoid/rhabdoid tumor

大型先天性黑素细胞痣伴非典型畸胎瘤/横纹肌样瘤

• DOI: 10.1002/pbc.24515
• 发表时间: 2013
• 期刊: Pediatr Blood Cancer
• 影响因子: 3.2
• 作者: Yamazaki F;Osumi T;Kosaki K;Mikami S;Hirato J;Shimada H.
• 通讯作者: Shimada H.