Clinicopathological study of pediatric gliomas with extensive myxoid change

伴有广泛粘液样改变的儿童胶质瘤的临床病理学研究

• 批准号: 17500220
• 负责人: HIRATO Junko
• 金额: $ 1.84万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500220/
• 关键词: Glioma; Childhood; Myxoid matrix; Histopathology; Immunohistochemistry; Oncogene; 臨床病理学

Ten cases with gliomas with extensive myxoid change were selected from files of brain tumors diagnosed at Gunma University Hospital and cases sent to the author for consultation, and were examined. Patient age of nine cases ranged between 1 and 16 years and 24-old year patient was added. All tumors except a cerebellar tumor arose in supratentorial region. Three cases had developed acute lymphoblastic leukemia(ALL) in their past history.Tumor tissues showed microcystic change, angiocentric pattern, and sparsely diffuse pattern with extensive myxoid change. Tumor cells appeared to have a tendency of aggregating to perivascular space. The tumors were divided into low-grade and high-grade groups from the aspects of anaplasia and proliferation ability. Five of seven high-grade tumors included small primitive cell component One of them consisted of only small primitive cells that were positive for synaptophysin, and showed high proliferation ability. It was histologically consistent with pri … More mitive neuroectodermal tumor (PNET). In addition to primitive cells, two cases were composed of differentiated astrocytes without anaplasia, and other two cases had diffusely proliferating glioma component showing anaplasia. Two cases without primitive component were similar to high grade astrocytoma, but the tumor cells hardly expressed glial fibrillary acidic protein (GFAP), but did vimentin. Other three cases were classified as low-grade glioma, including pilomyxoid astrocytoma, astrocytic tumor negative for GFAP, and oligodendroglioma-like tumor.Most myxoid gliomas were high-grade. In addition, they often harbored small primitive cell component Some of them were considered to be a variant of glioblastoma. Small primitive cells frequently expressed Olig2 or 5-100 protein. The finding was different from that of conventional PNET. APNET-like tumor did not overexpress EGFR or p53.Three cases developed myxoid glioma after remission of ALL by chemotherapy and/or radiotherapy. It is possible that myxoid gliomas may occur as secondary tumor or radiation-induced tumor. Less

从Gunma University医院诊断出的脑肿瘤的文件中选择了十个具有广泛粒细胞类动物的神经胶质瘤的病例，并检查了作者进行咨询的病例，并进行了检查。增加了9例患者年龄在1至16岁之间，并增加了24岁年龄的患者。除小脑肿瘤以外的所有肿瘤均在上部地区出现。三个病例在过去的历史中出现了急性淋巴细胞白血病（全部）。肿瘤组织显示了微囊的变化，血管中心的模式和稀疏的弥漫性模式，并具有广泛的粘液样变化。肿瘤细胞似乎具有聚集到血管周空间的趋势。肿瘤分为低级和高级基团，从碎屑和增殖能力的各个方面。七个高级肿瘤中有五个包括小原始细胞成分，其中一种仅由突触素阳性阳性的小原始细胞组成，并显示出高增殖能力。在组织学上，它与PRI相一致……更具降低的神经外科肿瘤（PNET）。除原始细胞外，两个病例还由没有异常的分化的星形胶质细胞组成，其他两种情况则具有不同的增生的神经胶质瘤成分，显示出异常。两种没有原始成分的病例与高级星形细胞瘤相似，但是肿瘤细胞几乎没有表达神经胶质纤维酸性蛋白（GFAP），但流膜蛋白。其他三例被归类为低度胶质瘤，包括毛类星形胶质细胞瘤，GFAP的星形胶质细胞肿瘤阴性和类似少突胶质瘤的肿瘤。大多数蛋白酶神经胶质瘤是高级的。在添加的添加，它们通常认为其中的一些原始细胞成分被认为是胶质性膜瘤的变体。小原始细胞经常表达寡核酸或5-100蛋白。该发现与常规PNET不同。 apnet样肿瘤没有过表达EGFR或p53。三例通过化学疗法和/或放疗后所有肿瘤性胶质瘤出现了。粘液样神经胶质瘤可能作为继发性肿瘤或辐射诱导的肿瘤发生。较少的

项目成果

Central PNETとperipheral PNET症例における臨床病理学的検討

中枢性 PNET 和外周性 PNET 病例的临床病理学检查

• 发表时间: 2006
• 作者: Kitao;Y.;Imai;Y.;Ozawa;K.;Kataoka;A.;Ikeda;T.;Soda;M.;Namekawa;K.;Kiyama;H.;Stern;DM.;Hori;O.;Wakamatsu;K.;Ito;S.;Itohara;S.;Takahashi;R.;Ogawa;S;本多 文昭
• 通讯作者: 本多 文昭

小児に発生し、豊富な組織球を含む右前頭部髄外腫瘍

右额叶髓外肿瘤发生于儿童，含有丰富的组织细胞。

• 发表时间: 2007
• 作者: Hirato J;Nakazato Y;平戸 純子;Hirato J;大石琢磨
• 通讯作者: 大石琢磨

Tumor arising in the middle cranial fossa of a74-year-old man with extensive brain edema

74岁男性中颅窝肿瘤伴广泛脑水肿

• 发表时间: 2007
• 期刊: Neuropathology 27
• 作者: Koitabashi M;Kanazawa T;Tamura K;Tsukada S;Suzuki M;Morikawa A;Ogawa C;Hirado J.;Tomomi Miyallaga;Nishihira Y;Tosaka M;平戸 純子;Junko Hirato
• 通讯作者: Junko Hirato

病理診断に役立つ免疫組織化学の新しいマーカー 脳腫瘍の診断への応用

有助于病理诊断的新型免疫组化标记物在脑肿瘤诊断中的应用

• 发表时间: 2007
• 期刊: 診断病理 24
• 作者: Koitabashi M;Kanazawa T;Tamura K;Tsukada S;Suzuki M;Morikawa A;Ogawa C;Hirado J.;Tomomi Miyallaga;Nishihira Y;Tosaka M;平戸 純子;Junko Hirato;平戸 純子;平戸 純子;平戸 純子
• 通讯作者: 平戸 純子

An eight-year survivor with multiple brain metastases of non-small lung cancer: an autopsy case

非小细胞肺癌多发脑转移的八年幸存者：尸检案例

• 发表时间: 2006
• 期刊: Anticancer research 26
• 作者: Tosaka M;Sato N;Hirato J;Fujimaki H;Yamaguchi R;Kohga H;Hashimoto K;Yamada M;Mori M;Saito N;Yoshimoto Y.;Hirato J;Hirato J;Hirato J.;Hirato J;Hirato J;Matsuda H;Kawamura H
• 通讯作者: Kawamura H