Genome-wide analysis of copy number variants in schizophrenia

精神分裂症拷贝数变异的全基因组分析

• 批准号: 22390223
• 负责人: OZAKI Norio
• 金额: $ 11.9万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390223/
• 关键词: 統合失調症; ゲノム; コピー数多型; 神経発達; CNV; コピー数変異

We have performed high resolution genome wide copy number (CNV) screening of Japanese schizophrenic patients. Besides the known large CNVs that are previously reported to be associated with schizophrenia, we found novel variations. Smaller CNVs were followed up using lymphoblastoid cell lines (LCL) in order to measure expressional impact. No association between VIPR2duplication and schizophrenia was identified. In conclusion, our study demonstrated that combination of high resolution CNV screening and transcriptomics is useful methodfor investigating genetic susceptibility to schizophrenia.

我们对日本精神分裂症患者进行了高分辨率全基因组拷贝数（CNV）筛查。除了之前报道的与精神分裂症相关的已知大 CNV 之外，我们还发现了新的变异。使用类淋巴母细胞系 (LCL) 跟踪较小的 CNV，以测量表达影响。未发现 VIPR2 重复与精神分裂症之间存在关联。总之，我们的研究表明，高分辨率 CNV 筛查和转录组学的结合是研究精神分裂症遗传易感性的有用方法。

项目成果

Myelin-related abnormality of schizophrenia: genetic, imaging and postmortem study.

精神分裂症的髓磷脂相关异常：遗传、影像学和尸检研究。

• 发表时间: 2012
• 作者: Yamamori H;Hashimoto R;Verrall L;Yasuda Y;Ohi K;Fukumoto M;Umeda-Yano S;Ito A;Takeda M;Ozaki N
• 通讯作者: Ozaki N

Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures

• DOI: 10.1016/j.schres.2009.12.024
• 发表时间: 2010-06
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: Makoto Takahashi;Hiroshi Hayashi;Yuichiro Watanabe;K. Sawamura;N. Fukui;J. Watanabe;T. Kitajima;Y. Yamanouchi;N. Iwata;K. Mizukami;T. Hori;K. Shimoda;H. Ujike;N. Ozaki;Kentaro Iijima;Kazuo Takemura;H. Aoshima;T. Someya

Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis

• DOI: 10.1002/ajmg.b.32043
• 发表时间: 2012-06-01
• 期刊: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
• 影响因子: 2.8
• 作者: Ohi, Kazutaka;Hashimoto, Ryota;Takeda, Masatoshi
• 通讯作者: Takeda, Masatoshi

Vulnerability in early life to changes in the rearing environment plays a crucial role in the aetiopathology of psychiatric disorders

• DOI: 10.1017/s1461145710001239
• 发表时间: 2011-05-01
• 期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
• 影响因子: 4.8
• 作者: Niwa, Minae;Matsumoto, Yurie;Nabeshima, Toshitaka
• 通讯作者: Nabeshima, Toshitaka

Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches.

利培酮治疗反应和精神分裂症易感性的新候选基因的鉴定：药物基因组学、小鼠表达和遗传病例对照关联方法之间的综合分析。

• 发表时间: 2010
• 期刊: Biol.Psychiatry 67
• 作者: Ikeda M;et.al.
• 通讯作者: et.al.