Investigation of the novel anti-angiogenesis therapy in an orthotopic implantation mouse model of human malignant pleural mesothelioma cells

人恶性胸膜间皮瘤细胞原位植入小鼠模型中新型抗血管生成疗法的研究

• 批准号: 22390166
• 负责人: SONE Saburo
• 金额: $ 11.07万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390166/
• 关键词: 非閉塞性肺疾患; 悪性胸膜中皮腫; 同所移植モデル; 血管新生; マイクロアレイ

The resistance against anti-VEGF therapy was investigated using orthotopic implantation mouse model of human malignant pleural mesothelioma cells. Although tumor angiogenesis was inhibited in the early phase ofanti-VEGF therapy, microvessel density was turned to increase in the late phase ofthe therapy, suggesting that the tumor acquired the resistance against anti-VEGF therapy. We found that the host FGF2 was up-regulated in the resistant tumor, and anti-FGFR therapy in combination with anti-VEGF therapy was more effective compared to anti-VEGF therapy alone. Angiogenic switch into different factors such as FGF2 seemed to play important role in the resistance against anti-VEGF therapy.

使用人类恶性胸膜间皮瘤细胞的原位植入小鼠模型研究了对抗VEGF疗法的耐药性。尽管在anti-VEGF疗法的早期阶段抑制了肿瘤血管生成，但在治疗的后期，微血管密度变为增加，这表明肿瘤获得了对抗VEGF疗法的耐药性。我们发现宿主FGF2在抗性肿瘤中被上调，与仅抗VEGF疗法相比，抗FGFR治疗与抗VEGF疗法结合使用更有效。血管生成转向不同因素（例如FGF2）似乎在抵抗抗VEGF治疗的抗性中起着重要作用。

项目成果

E7080 Suppresses Hematogenous Multiple Organ Metastases of Lung Cancer Cells with Nonmutated Epidermal Growth Factor Receptor

• DOI: 10.1158/1535-7163.mct-10-0707
• 发表时间: 2011-07-01
• 期刊: MOLECULAR CANCER THERAPEUTICS
• 影响因子: 5.7
• 作者: Ogino, Hirokazu;Hanibuchi, Masaki;Sone, Saburo
• 通讯作者: Sone, Saburo

Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma

抗平足蛋白抗体NZ-1对恶性间皮瘤的抗肿瘤作用

• 作者: Yasuhiko Nishioka;et al
• 通讯作者: et al

難治性呼吸器疾患の治療法の開発を目指して.

旨在开发顽固性呼吸系统疾病的治疗方法。

• 发表时间: 2012
• 期刊: 呼吸
• 作者: Miyake K;Tani K;Kakiuchi S;Suzuka C;Toyoda Y;Kishi J;Tezuka T;Yuasa S;Hanibuchi M;Aono Y;Nishioka Y;Sone S;Kohno N;Yasuhiko Yamamoto;西岡安彦
• 通讯作者: 西岡安彦

Endothelin 受容体拮抗剤による肺癌脳転移抑制効果の検討.

内皮素受体拮抗剂抑制肺癌脑转移的作用研究。

• 作者: 大塚憲司;他
• 通讯作者: 他

小細胞肺がん転移におけるDLL4-Notchシグナルの臓器特異性に関する検討

小细胞肺癌转移中DLL4-Notch信号的器官特异性检查

• 发表时间: 2010
• 作者: 倉本卓哉;他
• 通讯作者: 他