Evaluatuion ofstress-inducedactivation of quercetinand its multifunctional dynamics

应激诱导的槲皮素激活及其多功能动力学评价

• 批准号: 22380077
• 负责人: TERAO Junji
• 金额: $ 9.48万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380077/
• 关键词: 食品; ストレス; 発現制御; 分析化学; シグナル伝達、筋萎縮; β-βグルクロニダーゼ; 炎症; シグナル伝達; 筋萎縮; 筋委縮; β-グルクロニダーゼ; 分析科学; 潰瘍性大腸炎; フラボノイド

This study was aimed to evaluate the multifunctional mechanism of quercetin as a antioxidative ingredient derived from plant foods. Rodent experiments demonstrated that dietary quercetin protects the intestinal mucosa of digestive tract, blood vessel, central nervous system and muscle tissue from oxidative stress by promoting the antioxidant enzyme expression as well asdirect ROS-scavenging and suppression of oxidant enzymes. It is implied that de-conjugation reaction by macrophage participates in these multifunction of dietary quercetin.

本研究旨在评估槲皮素作为植物性食品抗氧化成分的多功能机制。啮齿动物实验表明，膳食槲皮素通过促进抗氧化酶的表达以及直接清除ROS和抑制氧化酶来保护消化道肠粘膜、血管、中枢神经系统和肌肉组织免受氧化应激。这表明巨噬细胞的解结合反应参与了膳食槲皮素的这些多功能作用。

项目成果

Functional food factors for the prevention of muscle atrophy

预防肌肉萎缩的功能性食品因素

• 发表时间: 2011
• 作者: Uno H;Akashi N;Watanabe 0;Watanabe N;J.Terao
• 通讯作者: J.Terao

Effect of quercetin and its glucuronide metabolites upon 6-hydroxydopamine-induced oxidative damage in neuor-"a cells

槲皮素及其葡萄糖苷酸代谢物对6-羟基多巴胺诱导的神经细胞氧化损伤的影响

• 发表时间: 2012
• 期刊: Free Radical Research
• 影响因子: 3.3
• 作者: Mukai r.;Kawabata K.;Otsuka S.;Ishisaka A.;Kawai y.;Ji Z-S.;Tsuboi H.;Terao J.
• 通讯作者: Terao J.

Effect of quercetin and its glucuronide metabolites upon 6-hydroxydopamineinduced oxidative damage in neuro-2a cells

槲皮素及其葡萄糖醛酸代谢物对6-羟基多巴胺诱导的neuro-2a细胞氧化损伤的影响

• 发表时间: 2012
• 期刊: Free Radi-cal Research
• 作者: Mukai R.;Kawabata K.;Otsuka S.;Ishisaka A.;Kawai Y.;Ji Z-S.;Tsuboi H.;Terao J.
• 通讯作者: Terao J.

A role of dietary flavonoids on oxidative stress in the central nervous system: attenuation of monoamine oxidase-A activity

膳食黄酮类化合物对中枢神经系统氧化应激的作用：单胺氧化酶 A 活性减弱

• 发表时间: 2012
• 作者: Keizo Takao;Katsunori Kobayashi;HideoHagihara;Koji Ohira;Keiko Toyama;HirotakaShoji;Hironori K Nakamura;Kayoko Esaki,Shigeki Furuya;Tsuyoshi Takagi;Noah Walton,Nobuhiro Hayashi;Hidenori Suzuki;MitsuyukiMatsumoto;Shunsuke Ishii;TsuyoshiMiyakaw;加藤衛拡;Terao J
• 通讯作者: Terao J

lavonoid and related compounds (Chapter 4. Bioavailability of Flavonols and Falvones

类黄酮和相关化合物（第 4 章：黄酮醇和黄酮的生物利用度

• 发表时间: 2012
• 作者: M. Piskula;K. Murota;J. Terao
• 通讯作者: J. Terao