The EMT and its associated metastatic potential induced by microenvironmental oncogenic stress in refractory ovarian cancer

难治性卵巢癌微环境致癌应激诱导的 EMT 及其相关转移潜能

• 批准号: 21689045
• 负责人: KAJIYAMA Hiroaki
• 金额: $ 17.56万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689045/
• 关键词: 上皮間葉転換(EMT); 卵巣癌; 腹膜播種; 薬剤耐性抗癌剤; 転写因子; 上皮間葉転換（EMT）; 薬剤耐性; 抗癌剤; 放射線耐性; 微小環境; 転移浸潤; 放射線治療; EMT誘導転写因子

We identified the novel EMT inducible transcriptional factor associated with the metastasis/invasion of ovarian cancer. Of these, ALX-1 and PLAG2positively influenced the formation of peritoneal metastasis. Furthermore, in drug-refractory ovarian cancer model, we clarified the novel mechanism via microRNA(miR-200c) in the link between enhanced metastatic capability and EMT. Furthermore, it was demonstrated that EMT in mesothelial cells, as well as carcinoma cells also play acrucial role in the development of peritoneal dissemination. Our current study suggested the EMT inducible factor targeting therapy may lead to a new approach for the treatment of progression to the peritoneum and drug-resistance of ovarian cancer.

我们发现了与卵巢癌转移/侵袭相关的新型 EMT 诱导转录因子。其中，ALX-1和PLAG2对腹膜转移的形成有正向影响。此外，在药物难治性卵巢癌模型中，我们通过 microRNA (miR-200c) 阐明了增强转移能力与 EMT 之间联系的新机制。此外，研究表明间皮细胞以及癌细胞中的 EMT 在腹膜播散的发展中也发挥着至关重要的作用。我们目前的研究表明EMT诱导因子靶向治疗可能为治疗卵巢癌腹膜进展和耐药性提供新方法。

项目成果

The survival impact of adjuvant paclitaxel and carboplatin for early stage ovarian clear-cell carcinoma with complete surgical staging

紫杉醇和卡铂辅助治疗对完整手术分期的早期卵巢透明细胞癌的生存影响

• DOI: 10.1159/000327924
• 发表时间: 2011
• 期刊: Gynecol Obstet Invest
• 作者: Kajiyama H;Shibata K;他
• 通讯作者: 他

Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line

顺铂耐药卵巢卵黄囊肿瘤细胞的建立及顺铂耐药机制研究

• DOI: 10.1159/000320744
• 发表时间: 2011
• 期刊: Gynecol Obstet Invest
• 作者: Shibata K;Kajiyama H;他
• 通讯作者: 他

Is There Survival Benefits Performing Retroperitoneal Systemic Lymphadenectomy in Advanced Epithelial Ovarian cancer

对晚期上皮性卵巢癌进行腹膜后全身淋巴结切除术是否有生存益处

• 发表时间: 2010
• 作者: Hirosawa T;Kajiyama H;Sekiya R;Shibata K;Kikkawa F.
• 通讯作者: Kikkawa F.

Does selecting the fertility-sparing surgery in young women with stage Iovarian cancer lead to a poorer survival outcome

对患有阶段性 Iovarian 癌症的年轻女性选择保留生育能力的手术是否会导致较差的生存结果

• 发表时间: 2010
• 作者: Kajiyama H;Shibata K;Suzuki S;Ino K;Nawa A;Kawai M;Nagasaka T;Kikkawa F.
• 通讯作者: Kikkawa F.

Does selecting the fertility-sparing surgery in young women with stage I ovarian cancer lead to a poorer survival outcome

患有 I 期卵巢癌的年轻女性选择保留生育能力的手术是否会导致较差的生存结果

• 发表时间: 2010
• 作者: Nakamura-Ishizu A;Okuno Y;Omatsu Y;Okabe K;Morimoto J;Uede T;Nagasa- wa T;Suda T;Kubota Y;江木盛時;Kajiyama H
• 通讯作者: Kajiyama H