Functional significance of integrin-αvβ3 in the regulation of metastatic potential of malignant melanoma and its therapeutic implication

整合素-αvβ3在调节恶性黑色素瘤转移潜能中的功能意义及其治疗意义

• 批准号: 21689031
• 负责人: JINUSHI Masahisa
• 金额: $ 7.74万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689031/
• 关键词: 腫瘍免疫; 免疫療法; 皮膚腫瘍学; 腫瘍生物学; 臨床腫瘍学; 悪性黒色腫; インテグリンαvβ3; MFG-E8; 抗癌剤耐性; DNA損傷応答; 抗腫瘍免疫; 死細胞貪食; 樹状細胞

We evaluated the role of integrin-αvβ3 on the regulation of prognosis and therapeutic response of malignant melanoma. The melanoma cells that acquire the resistance to anticancer drugs displayed a significant upregulation of integrin-αvβ3. The integrin-αvβ3 on the chemoresistant melanoma manipulates dendritic cells to induce tolerogenic activities, thereby impairing antitumor immune responses. These findings verified novel molecular machineries whereby tumor resistance to anticancer therapeutics is associated with impairment of host antitumor immunity.

我们评估了整合素-αvβ3 在调节恶性黑色素瘤的预后和治疗反应中的作用，获得抗癌药物耐药性的黑色素瘤细胞表现出整合素-αvβ3 的显着上调。诱导耐受活性，损害抗肿瘤免疫反应，从而验证了肿瘤抗癌的新分子机制。治疗与宿主抗肿瘤免疫受损有关。

项目成果

The role of tumor-derived MFG-E8 in triggering chemoresistance and immune suppression in patients with various solid tumors

肿瘤源性MFG-E8在引发多种实体瘤患者化疗耐药和免疫抑制中的作用

• 发表时间: 2009
• 作者: Masahisa Jinushi;et al.
• 通讯作者: et al.

MFG-E8: Negative regulator and potential biomarker to predict the clinical activities of GVAX

MFG-E8：预测 GVAX 临床活性的负调节因子和潜在生物标志物

• 发表时间: 2009
• 作者: Saito Y;et al.;Komaniwa S.;Takayoshi Suganami;佐藤佳乃子;Yoshida K;Jinushi M.
• 通讯作者: Jinushi M.

Milk-fat globule EGF-8 triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms

乳脂肪球 EGF-8 通过协调的细胞自主和免疫介导机制触发肿瘤破坏

• 发表时间: 2009
• 期刊: Journal of Experimental Medicine 206
• 作者: Masahisa Jinushi;et al.
• 通讯作者: et al.

The critical role of MFG-E8 in inflammation and cancer

MFG-E8 在炎症和癌症中的关键作用

• 发表时间: 2009
• 作者: T. Suganami;et al;佐藤佳乃子;Masuda K.;Jinushi M & Tahara H.
• 通讯作者: Jinushi M & Tahara H.

Active immunotherapy induces antibody responses that target tumor angiogenesis.

• DOI: 10.1158/0008-5472.can-10-1852
• 发表时间: 2010-12-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Schoenfeld J;Jinushi M;Nakazaki Y;Wiener D;Park J;Soiffer R;Neuberg D;Mihm M;Hodi FS;Dranoff G
• 通讯作者: Dranoff G