Effect of liquid diet on purkinje cells in cerebellum

流质饮食对小脑浦肯野细胞的影响

• 批准号: 21792062
• 负责人: YABUSHITA Tadachika
• 金额: $ 2.66万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792062/
• 关键词: 小脳; 液状飼料; 顎関節侵害受容器; 閉口筋筋紡錘; 電気生理; フィードバック; 軟食化; 学習; 咀嚼運動; 長期抑圧

Recently, it has been shown that prolonged feeding on liquid diet after being weaned impedes functional development and leads to immature mastication in growing rats. Since jaw muscle spindles play an important role in the control of jaw movements during normal masticatory function, in this study we investigated the effect of prolonged feeding on liquid diet after being weaned on the functional development of jaw-closing muscle spindles in growing rats. Soon after weaning, 40 female Wistar rats were divided into two equal groups. The control group fed on solid diet and the experimental group fed on liquid diet. At 5, 7, 9 and 11 weeks, the rats were anesthetized and the response of the masseter muscle spindles to ramp-and-hold jaw stretches were recorded from the mesencephalic trigeminal nucleus. In the experimental groups, both the dynamic and the static indices were significantly lower than those of the control groups at the age of 5, 7, 9 and 11 weeks old. There was no significant change within the same group during the experimental period in both indices. These results suggest that long-term masticatory functional change due to liquid diet feeding may impede maturation of the functional properties of jaw-closing muscle spindles, leading to immature mastication in growing rats.

最近，已经表明，断奶后长时间以液体饮食为食，阻碍了功能发展，并导致生长大鼠的未成熟咀嚼。由于下颌肌肉纺锤体在正常咀嚼功能期间的颌骨运动中起着重要作用，因此在这项研究中，我们研究了长期喂养对液体饮食的效果，因为它们对成长大鼠的颌骨关闭肌肉纺锤体的功能发展后。断奶后不久，将40只雌性Wistar大鼠分为两组。喂食固体饮食的对照组和液体饮食中喂养的实验组。在5、7、9和11周时，将大鼠麻醉，并从中脑脑三叉神经核中记录了咬肌对坡道和矮的下颌伸展的反应。在实验组中，动态和静态指标都显着低于5、7、9和11周大的对照组。在两个指数的实验期间，同一组内没有显着变化。这些结果表明，由于液体饮食喂养而引起的长期咀嚼功能变化可能会妨碍粘合肌肉纺锤体的功能特性的成熟，从而导致生长大鼠的未成熟咀嚼。

项目成果

液状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について

流质饲料喂养对生长大鼠颞下颌关节伤害感受器的影响

• 发表时间: 2010
• 作者: 平沼摩耶;小海暁;藪下忠親;小野卓史
• 通讯作者: 小野卓史

咬合高径増加に対するラット顎関節機械受容器の機能適応について

大鼠颞下颌关节机械感受器对咬合高度增加的功能适应

• 发表时间: 2010
• 作者: 内藤聡美;石田宝義;小海暁;藤田紘一;柴田真衣;藪下忠親;小野卓史
• 通讯作者: 小野卓史

Functional adaptability of temporomandibular joint mechanoreceptors after an increase in the occlusal vertical dimension in rats

• DOI: 10.2319/082010-489.1
• 发表时间: 2011-05-01
• 期刊: ANGLE ORTHODONTIST
• 影响因子: 3.4
• 作者: Naito, Satomi;Ishida, Takayoshi;Ono, Takashi
• 通讯作者: Ono, Takashi

液状飼料飼育が成長期ラットの閉口筋筋紡錘に与える影響

流质饲料喂养对生长大鼠闭口肌肌梭的影响

• 发表时间: 2010
• 期刊: 口腔病学会誌 77巻
• 作者: Naito S;Ishida T;Kokai S;Fujita K;Shibata M;Yabushita T;Ono T;柴田真衣
• 通讯作者: 柴田真衣

状飼料飼育が成長期ラットの顎関節侵害受容器に及ぼす影響について

喂养对生长大鼠颞下颌关节伤害感受器的影响

• 发表时间: 2010
• 作者: 平沼摩耶;小海暁;藪下忠親;小野卓史
• 通讯作者: 小野卓史