Effects of GABAergic compounds on the accumbal catecholaminergic activity

GABA能化合物对累积儿茶酚胺能活性的影响

• 批准号: 21792034
• 负责人: UCHIDA Takuya
• 金额: $ 1.58万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792034/
• 关键词: GABA; カテコラミン; 大脳基底核; 抗不安薬; 口腔ジスキネジア; SKF38393; 線条体; ドパミン; 脳微小透析法; Ca^<2+>; D_1受容体; ラット; dexamhetamine; reseine; α-methvl-p-tvrosine

The ventral part of striatum called nucleus accumbens is one of the terminal areas of the mesolimbic dopaminergic neurons. It has been shown that the GABA receptor subtype agonists failed to decrease, but its antagonists increased the accumbal dopamine (DA) efflux. Since the GABA synthesis inhibitor enhanced the accumbal DA efflux, but the involvement of accumbal GABA receptor subtypes are unknown. Therefore, we investigated the roles of GABA receptor subtypes in the increase of accumbal DA efflux in freely moving rats by using the in vivo brain microdialysis technique. SKF38393, a benzazepine derivative D_1 receptor agonist is widely used in order to examine the GABA-DA interaction in the striatal structures. SKF38393 is known to increase the striatal DA efflux when applied locally into the dorsal striatum. We analysed the roles of the Ca^<2+> and the intracellular DA pools in the SKF38393-induced striatal DAefflux.

纹状体的腹侧部分称为伏隔核，是中断多巴胺能神经元的末端区域之一。已经表明，GABA受体亚型激动剂无法降低，但其拮抗剂增加了伏托胺（DA）外排。由于GABA合成抑制剂增强了伏da外排，但伏托Gaba受体亚型的参与尚不清楚。因此，我们通过使用体内脑微透析技术研究了GABA受体亚型在自由移动大鼠中伏da外排的作用。 SKF38393，苯唑衍生物D_1受体激动剂被广泛使用，以检查纹状体结构中的GABA-DA相互作用。已知SKF38393在局部应用于背纹状体时会增加纹状体DA外排。我们分析了Ca^<2+>和细胞内DA池在SKF38393诱导的纹状体Daefflux中的作用。

项目成果

Dopamine D_1-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393.

多巴胺 D_1 样受体在纹状体应用 SKF38393 诱导的纹状体多巴胺增加中仅发挥次要作用。

• 发表时间: 2010
• 期刊: Eur J Pharmacol 648
• 作者: Sekino R;Saigusa T;Aono Y;Uchida T;Takada K;Oi Y;Koshikawa N;Cools AR.
• 通讯作者: Cools AR.

Dopamine D1-like receptors play only a minor role in the increase of striatal dopamine induced by striatally applied SKF38393

多巴胺 D1 样受体在纹状体应用 SKF38393 诱导的纹状体多巴胺增加中仅发挥次要作用

• 发表时间: 2010
• 期刊: European Journal of Pharmacology
• 影响因子: 5
• 作者: Sekino R;Saigusa T;Aono Y;Uchida T;Takada K;Oi Y;Koshikawa N;Cools AR.;Reiko Sekino
• 通讯作者: Reiko Sekino

ラット線条体背側部へのSKF38393局所投与で誘発される細胞外DA量の増加におけるCa^<2+>の関与

Ca^2+参与SKF38393局部给予大鼠背侧纹状体诱导的细胞外DA量增加

• 发表时间: 2010
• 作者: 関野麗子;三枝禎;青野悠里;内田琢也;大井良之;越川憲明
• 通讯作者: 越川憲明