Placenta as a target of influenza virus infection

胎盘作为流感病毒感染的目标

• 批准号: 21791574
• 负责人: AIZAWA Shihoko
• 金额: $ 1.08万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791574/
• 关键词: 微生物; 胎盤; インフルエンザウイルス; 徴生物

We report here placenta as a target organ of influenza A virus. A choriocarcinoma cell line and immortalized human invasive trophoblasts were challenged with an influenza virus strain A/Udorn/72 and /or clinical isolate of H1N1/09 influenza virus. We observed viral replication in both viruses, while cytotoxicity was less prominent in H1N1/09.

我们在此报告胎盘是甲型流感病毒的靶器官。用流感病毒株 A/Udorn/72 和/或 H1N1/09​​ 流感病毒的临床分离株攻击绒毛膜癌细胞系和永生化人类侵袭性滋养层细胞。我们观察到这两种病毒都存在病毒复制，而 H1N1/09​​ 病毒的细胞毒性不太明显。

项目成果

H1N1/09 Influenza A Virus Infection of Immortalized First Trimester Human Trophoblast Cell Lines

• DOI: 10.1111/j.1600-0897.2012.01172.x
• 发表时间: 2012-09-01
• 期刊: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
• 影响因子: 3.6
• 作者: Komine-Aizawa, Shihoko;Suzaki, Ai;Hayakawa, Satoshi
• 通讯作者: Hayakawa, Satoshi