The mechanism of ERK activation via Gonadotrophin receptor activation on ovarian surface epithelial cells

卵巢表面上皮细胞促性腺激素受体激活激活ERK的机制

• 批准号: 21791541
• 负责人: HIRAKAWA Takashi
• 金额: $ 1.5万
• 依托单位: Gunma Institute of Public Health and Environmental Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791541/
• 关键词: FSHレセプター; LHレセプター; ゴナドトロピン; 卵巣癌

The expression of Gonadotrophin receptors mRNA and protein were confirmed in OSE-29 cells, derived from ovarian surface epithelial cells. The activation of ERK were observed in the presence of Gonadotrophins in dose-dependent manner. MEK inhibitor, U0126 inhibited the activation of ERK via Gonadotrophin receptor activation.

促性腺激素受体 mRNA 和蛋白的表达在源自卵巢表面上皮细胞的 OSE-29 细胞中得到证实。在促性腺激素存在的情况下，观察到 ERK 的激活呈剂量依赖性。 MEK 抑制剂 U0126 通过促性腺激素受体激活抑制 ERK 的激活。