The radiosensitivity and effects of hypoxia in human cancer stem cells

人类癌症干细胞的放射敏感性和缺氧的影响

• 批准号: 21791235
• 负责人: TAKAHASHI Momoko
• 金额: $ 2.66万
• 依托单位: Japan Atomic Energy Agency (2010)National Institute of Radiological Sciences (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791235/
• 关键词: がん幹細胞; 放射線; 低酸素

Recently several studies demonstrated that there is a small fraction in solid tumor which is highly resistant to ionizing radiation and that the radioresistant tumor cells often express some stem cell markers. This small population of cells is characteristic of stem cells and called “cancer stem cell”. It is highly resistant to ionizing radiation and it is suggested that resistance of cancers to both radiation and chemotherapeutic agents can be attributed to the features of the cancer stem cells. The purpose of this study is the analysis of cancer stem-like cells derived from established glioblastoma cell line and radiosensitivity in cancer stem-like cells using X-rays and heavy ion beam. As a result, it has been shown that sub population of human glioblastoma cell line A172 grown in non serum free medium showed cancer stem cell-like property and radioresistance to both X-rays and heavy ion beam.

最近的一些研究表明，实体瘤中有一小部分对电离辐射具有高度抵抗力，并且抗辐射的肿瘤细胞经常表达一些干细胞标志物，这部分细胞具有干细胞的特征，被称为“癌症干细胞”。它对电离辐射具有高度抵抗力，并且表明癌症对放射和化疗药物的抵抗力可归因于癌症干细胞的特征。本研究的目的是分析源自已建立的癌症干细胞样细胞。使用 X 射线和重离子束研究胶质母细胞瘤细胞系和癌症干细胞样细胞的放射敏感性 结果表明，在无血清培养基中生长的人胶质母细胞瘤细胞系 A172 亚群显示出癌症干细胞样特性。以及对 X 射线和重离子束的抗辐射性。

项目成果

脳腫瘍細胞u251のρ0細胞株におけるCD133の発現とその関連性

CD133在脑肿瘤细胞U251ρ0细胞系中的表达及其关系

• 发表时间: 2009
• 作者: 高橋桃子;藤森亮;岡安隆一
• 通讯作者: 岡安隆一

Cancer stem-like cells from a glioblastoma cell line is resistant to X-rays and carbon-ion beams

来自胶质母细胞瘤细胞系的癌症干细胞对 X 射线和碳离子束具有抵抗力

• 发表时间: 2011
• 作者: Akira;Fujimori
• 通讯作者: Fujimori

Study of radiosensitivity in cancer stem-like cells from a glioblastoma cell line

胶质母细胞瘤细胞系癌症干细胞的放射敏感性研究

• 发表时间: 2011
• 作者: Takahashi;Momoko
• 通讯作者: Momoko