Management of chronic liver diseases with polyunsaturated fatty acids and anti-oxidative food substance

用多不饱和脂肪酸和抗氧化食品物质治疗慢性肝病

• 批准号: 13680156
• 负责人: OKITA Misako
• 金额: $ 2.3万
• 依托单位: Okayama Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680156/
• 关键词: polyunsaturated fatty acid; arachidonic acid; eicosapentaenoic acid; vitamin E; oxidative stress; cytokine; erythrocyte; liver cirrhosis; chronic hepatitis; food intake; チオレドキシン; EPA; HCV; 肝癌; 過酸化脂質; α-トコフェロール; 肝障害; 肝硬度; 栄養療法

1.To elucidate the significance of arachidonic acid deficiency on the clinical pathophysiology of liver cirrhosis, fatty acid composition of mononuclear cells, plasma α-tocopherol and TBARS and serum TNF-α were analyzed. Significantly low level of arachidonic acid and EPA were observed in mononuclear cell phospholipids, and the arachidonic acid level correlated positively with lymphocyte and platelet counts. Significantly low level of α-tocopherol and high level of TBARS were observed in cirrhotic patients with hepatocellular carcinoma. From these results, it was suggested that arachidonic acid deficiency in mononuclear cells may have an important role in the progression of liver cirrhosis and that nutritional management preventing arachidonic acid deficiency may be useful in the treatment of liver cirrhosis.2.The effects of vitamin E supplementation on the fatty acid composition of RBC and pathophysiology in HCV infected patients were investigated. The serum ALT activity was improved … More in 5 of 8 patients. The arachidonic acid and docosahexaenoic acid levels and polyunsaturated fatty acid/saturated fatty acid (P/S) ratio in RBC, which were significantly lower in the patients than controls, were elevated following vitamin E supplementation. The improvement in fatty acid composition was observed particularly in the patients who responded to the vitamin E therapy. A possibility of vitamin E therapy for the prevention of disease progression in HCV infected chronic liver diseases was suggested.3.The effects of dietary polyunsaturated fatty acid and α-tocopherol intake on serum ALT activity were evaluated comparing the habitual food intake and plasma fatty acid composition in cirrhotic patients living in two different regions in Japan. Serum ALT activity correlated negatively with plasma arachidonic acid and α-tocopherol levels. Dietary intake of linoleic acid and the P/S ratio in dietary fat correlated positively with serum ALT. A significance of dietary intake of polyunsaturated fatty acid and anti oxidative vitamins was postulated. Less

1.为了阐明花生四烯酸缺乏对肝硬化临床病理生理学的意义，分析了单核细胞的脂肪酸组成、血浆α-生育酚和TBARS以及血清TNF-α，观察到花生四烯酸和EPA的水平显着降低。单核细胞磷脂，花生四烯酸水平与淋巴细胞和血小板计数呈正相关。在患有肝细胞癌的肝硬化患者中观察到α-生育酚和高水平的TBARS，从这些结果表明，单核细胞中的花生四烯酸缺乏可能在肝硬化的进展中发挥重要作用，并且营养管理可以预防花生四烯酸缺乏。可能有助于治疗肝硬化。2.研究补充维生素E对HCV感染患者的红细胞脂肪酸组成和病理生理学的影响。 8 名患者中有 5 名的 ALT 活性得到改善，服用维生素后患者的花生四烯酸和二十二碳六烯酸水平以及红细胞中的多不饱和脂肪酸/饱和脂肪酸 (P/S) 比率显着低于对照组。 E补充。特别是在对维生素E治疗有反应的患者中观察到脂肪酸组成的改善，提出了维生素E治疗预防HCV感染的慢性肝病疾病进展的可能性。3.饮食的影响。通过比较日本两个不同地区的肝硬化患者的习惯性食物摄入量和血浆脂肪酸组成，评估了多不饱和脂肪酸和 α-生育酚摄入量对血清 ALT 活性的影响，血清 ALT 活性与血浆花生四烯酸和 α-生育酚水平呈负相关。膳食中亚油酸的摄入量和膳食脂肪中的 P/S 比值与血清 ALT 呈正相关，推测膳食中多不饱和脂肪酸和抗氧化维生素的摄入量具有显着性。

项目成果

冨岡加代子: "肝癌合併及び非合併肝硬変における栄養状態の比較と栄養療法に関する考察"栄養-評価と治療. 18・4. 487-491 (2001)

富冈嘉代子：“肝硬化伴肝癌和不伴肝癌的营养状况比较及营养治疗的考虑”营养-评估和治疗18・4（2001）。

太田泰子, 笹川貴代, 冨岡加代子, 永井亜矢子, 鈴木和彦, 山田剛太郎, 沖田美佐子: "C型慢性肝炎・肝硬変例の赤血球膜脂肪酸組成からみたビタミンE投与の評価"栄養-評価と治療. 20(6). 595-598 (2003)

Yasuko Ota、Takayo Sasakawa、Kayoko Tomioka、Ayako Nagai、Kazuhiko Suzuki、Gotaro Yamada、Misako Okita：“从慢性丙型肝炎和肝硬化患者的红细胞膜脂肪酸组成的角度评价维生素 E 的给药” 营养 -评估和治疗。20（6）。

Sabina Mahmood, Gotaro Yamada, Gouichi Niiyama, Miwa Kawanaka, Kazumi Togawa, Miho Sho, Toshio Ito, Takayo Sasagawa, Misako Okita, Hajime Nakamura, Junji Yodoi: "Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral h

Sabina Mahmood、Gotaro Yamada、Gouichi Niiyama、Miwa Kawanaka、Kazumi Tokawa、Miho Sho、Toshio Ito、Takayo Sasakawa、Misako Okita、Hajime Nakamura、Junji Yodoi：“维生素 E 对病毒性肝炎患者血清转氨酶和硫氧还蛋白水平的影响

太田 泰子: "C型慢性肝炎・肝硬変例の赤血球膜脂肪酸組成からみたビタミンE投与の評価"栄養-評価と治療. 20・5. 595-598 (2003)

Yasuko Ota：“从慢性丙型肝炎和肝硬化患者的红细胞膜脂肪酸组成的角度评估维生素E的施用”营养-评估和治疗（2003年）。

Mahmood S.: "Effect of vitamin E on serum aminotransferase and thioredoxin levels in patients with viral hepatitis C"Free Radic res. 37・7. 781-785 (2003)

Mahmood S.：“维生素 E 对丙型病毒性肝炎患者血清转氨酶和硫氧还蛋白水平的影响”Free Radic res. 781-785。