N-6 and n-3 polyunsaturated fatty acid supplement in the treatment of liver cirrhosis.

补充N-6和N-3多不饱和脂肪酸治疗肝硬化。

• 批准号: 07680037
• 负责人: OKITA Misako
• 金额: $ 1.41万
• 依托单位: Okayama Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680037/
• 关键词: liver cirrhosis; alcoholic liver injury; arachidonic acid; 6-keto prostaglandin F1alpha; leukotriene B4; dietary fat; fatty acid; アラキドン酸油; 亜鉛; 脂質過酸化; プロスタグランディンE_2; ロイコトリエンB_4; 脂肪酸栄養; n-3脂肪酸; n-6脂肪酸; リン脂質

1. The serum phospholipid contents and the fatty acid compositions in the phospholipids were analyzed in 24 cirrhotic patients, and they were compared with those of control patients with no liver disease. Serum phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidylethanolamine (PE) levels in the cirrhotic patients were significantly lower than those in the control patients. Significant decreases in the molar composition of arachidonic acid in PC, PI and PE were recognized in the serum of cirrhotic patients compared with the levels in the controls. The arachidonic acid/linoleic acid molar ratios in the serum PI and PE of cirrhotic patients were also significntly lower than those of the controls, as was the docosahexaenoic acid contents in the patients. None of the patients showed deficient dietary intake of polyunsaturated fatty acid in the cirrhotic patients. It is concluded that the metabolism of linoleic acid to arachidonic acid and alpha-linolenic acid to DNA may be de … More layd in the cirrhotic liver, and supplement of arachidonic acid and DHA may be useful for the nutritional treatment of liver cirrhotic patients.2. Ethanol-treated rats were fed with two kinds of dietary fat, lard or arachidonic acid-rich oil, for 14days. Ethanol was administered by gavage at a single daily dose of 3g/kg body weight. Significantly lower levels of arachidonic acid and arachidonic/linoleic acid ratio and higher levels oleic acid in liver phospholipid were observed in the ethanol-treated fed with lard compared to sucrose administered control rats. The arachidonic acid-rich oil-diet induced a marked increase of arachidonic acid and subsequent significant decrease of linoleic acid both in the liver and plasma phospholipid in ethanol-treated rats. Oleic acid in the plasma and liver triglyceride in ethanol-treated rats were also markedly decreased by feeding arachidonic acid-rich oil. The level of 6-keto prostaglandin F1alpha was elevated markedly in the ethanol-treated rats fed with arachidonic acid rich oil. Liver leukotriene B4 level was not increased by feeding arachidonic acid-rich oil. These results may suggest some beneficial effects of arachidonic acid supplement to the patients with alcoholic liver injury or liver cirrhosis. Less

1.分析24例肝硬化患者的血清磷脂含量及磷脂中的脂肪酸组成，并与无肝病对照患者的血清磷脂酰胆碱（PC）、磷脂酰肌醇（PI）和磷脂酰乙醇胺（PE）进行比较。肝硬化患者的摩尔浓度显着低于对照患者。与对照组相比，肝硬化患者血清中PC、PI和PE中的花生四烯酸/亚油酸摩尔比也显着低于对照组。与对照组相同，患者中的二十二碳六烯酸含量也相同。得出的结论是，肝硬化患者中没有一个患者表现出多不饱和脂肪酸的饮食摄入不足。亚油酸向花生四烯酸和α-亚麻酸向DNA的代谢可能在肝硬化肝脏中进行，补充花生四烯酸和DHA可能有助于肝硬化患者的营养治疗。 2．饲喂两种膳食脂肪：猪油或富含花生四烯酸的油，连续 14 天，每日单剂量灌胃乙醇。与给予蔗糖的对照饮食相比，在用猪油喂养的乙醇处理的大鼠中观察到3g/kg体重的花生四烯酸和花生四烯酸/亚油酸的比例显着降低，并且油酸水平较高。乙醇处理的大鼠的肝脏和血浆磷脂中的亚油酸随后显着降低。喂食富含花生四烯酸的油也显着降低了乙醇治疗大鼠血浆和肝脏甘油三酯的水平。喂食富含花生四烯酸的肝脏白三烯油的乙醇治疗大鼠的6-酮前列腺素F1α水平显着升高。饲喂富含花生四烯酸的油并未增加 B4 水平。这些结果可能表明补充花生四烯酸对酒精性肝损伤或肝脏患者有一些有益作用。肝硬化.少

项目成果

渡辺明治: "肝硬変例におけるアラキドン酸欠乏と肝発癌" Pharma Medica. 15・3. 168-180 (1997)

Meiji Watanabe：“肝硬化病例中的花生四烯酸缺乏和肝癌发生”Pharma Medica 15・3（1997）。