Study for preventing epidemic of viral zoonoses in Japan and theAmerican Continents

日本和美洲大陆病毒性人畜共患病流行预防研究

• 批准号: 21405035
• 负责人: KARIWA Hiroaki
• 金额: $ 11.56万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21405035/
• 关键词: 人獣共通感染症; ハンタウイルス; ウエストナイルウイルス; げっ歯類; 鳥類; メキシコ

Three novel hantaviruses were detected in Mexican rodents. The antibody detection method for various hantavirus infections was developed. Five of six monoclonal antibodies to nucleocapsid protein (NP) of Mexican hantavirus were broadly reacted with NPs of rodent-borne hantaviruses. Glycosylation of West Nile virus E protein made great influence in the pathogenesis in chicks infected with West Nile virus.

在墨西哥啮齿动物中检测到了三个新型汉坦病毒。开发了各种汉坦病毒感染的抗体检测方法。墨西哥汉塔病毒的六种单克隆抗体中有六种与啮齿动物hantavirus的NP广泛反应。西尼罗河病毒蛋白的糖基化对感染了西尼罗河病毒的雏鸡的发病机理产生了很大影响。

项目成果

Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan

• DOI: 10.1292/jvms.10-0350
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF VETERINARY MEDICAL SCIENCE
• 影响因子: 1.2
• 作者: Yoshii, Kentaro;Mottate, Keita;Takashima, Ikuo
• 通讯作者: Takashima, Ikuo

Genetic diversity of hantaviruses in Mexico: Identification of three novel hantaviruses from Neotominae rodents

• DOI: 10.1016/j.virusres.2011.11.013
• 发表时间: 2012-02-01
• 期刊: VIRUS RESEARCH
• 影响因子: 5
• 作者: Kariwa, Hiroaki;Yoshida, Haruka;Takashima, Ikuo
• 通讯作者: Takashima, Ikuo

Isolation of Hokkaido virus, genus Hantavirus, using a newly established cell line derived from the kidney of the grey red-backed vole (Myodes rufocanus bedfordiae)

使用源自灰红背田鼠（Myodes rufocanus bedfordiae）肾脏的新建立的细胞系分离北海道病毒（汉坦病毒属）

• DOI: 10.1099/vir.0.045377-0
• 发表时间: 2012
• 期刊: J Gen Virol
• 影响因子: 3.8
• 作者: Sawada K;Funakawa S;Kosaki T;Sanada T
• 通讯作者: Sanada T

Needle-free jet injection of DNA and protein vaccine of the far-eastern subtype of tick-borne encephalitis virus induces protective immunity in mice

无针喷射蜱传脑炎病毒远东亚型DNA和蛋白疫苗诱导小鼠保护性免疫

• DOI: 10.1111/j.1348-0421.2011.00389.x
• 发表时间: 2011
• 期刊: Microbiol Immunol
• 影响因子: 2.6
• 作者: Omori-Urabe Y;et al.
• 通讯作者: et al.

ダニ媒介性フラビウイルスによる中枢神経系障害に関わるウイルス因子の同定

蜱传黄病毒引起的中枢神经系统疾病相关病毒因子的鉴定

• 发表时间: 2012
• 作者: Wang H;Yuan Z;Barnes E;Yuan M;Li C;Fu Y;Xia X;Li G;Newton P;Vongsouvath M;Klenerman P;Pybus OG;Murphy D;Abe K;Lu L;好井健太朗ら
• 通讯作者: 好井健太朗ら