Prediction of the genetic risk associated with lifestyle-related diseases in a population based cohort study

基于人群的队列研究预测与生活方式相关疾病相关的遗传风险

• 批准号: 21390209
• 负责人: YOKOTA Mitsuhiro
• 金额: $ 10.98万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390209/
• 关键词: 前向きコホート; 地域住民; 遺伝子; 生活習慣病; ゲノム疫学

The discovery of genetic risk factors for many common diseases in the past couple of years has been enormously exciting. But we are still in the early stages of this revolution. We know, from studies of families and identical twins, that most diseases like diabetes are highly heritable, with, on average, about 50 percent of the risk attributable to genetics. Yet our genetic analysis has so far discovered less than 10 percent of that hereditary component.Therefore, the identification of new genomic variations that are associated with common diseases including coronary artery diseases(CADs), type 2 diabetes mellitus, and hypertension have to be made future efforts.

过去几年，许多常见疾病的遗传风险因素的发现非常令人兴奋。但我们仍处于这场革命的早期阶段。通过对家庭和同卵双胞胎的研究，我们知道大多数疾病（如糖尿病）具有高度遗传性，平均而言，大约 50% 的风险归因于遗传。然而，迄今为止，我们的基因分析只发现了不到 10% 的遗传成分。因此，必须鉴定与冠状动脉疾病 (CAD)、2 型糖尿病和高血压等常见疾病相关的新基因组变异。未来的努力。

项目成果

Relation of functional and morphological changes in mitochondria to myocardial contractile and relaxation reserves in asymptomatic to mildly symptomatic patients with hypertrophic cardiomyopathy

• 发表时间: 2009
• 作者: Kazumasa Unno;S. Isobe;H. Izawa;X. Cheng;Masakazu Kobayashi;A. Hirashiki;Takashi Yamada;Ken Harada;S. Ohshima;A. Noda;K. Nagata;Katsuhiko Kato;M. Yokota;T. Murohara

THE RATIO OF SERUM ADIPONECTIN LEVEL TO HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE IS A POWERFUL INDEX OF METABOLIC SYNDROME IN AN AGED JAPANESE POPULATION : RESULTS FROM THE KING STUDY

血清脂联素水平与胰岛素抵抗稳态模型评估的比率是日本老年人群代谢综合征的有力指标：King 研究的结果

• 发表时间: 2010
• 作者: Monma Y;Niu K;Iwasaki K;Tomita N;Nakaya N;Hozawa A;Kuriyama S;Takayama S;Seki T;Takeda T;Yaegashi N;Ebihara S;Arai H;Nagatomi R;Tsuji I;Mitsuhiro YOKOTA
• 通讯作者: Mitsuhiro YOKOTA

Exercise Training Alters Left Ventricular Geometry and Attenuates Heart Failure in Dahl Salt-Sensitive Hypertensive Rats

• DOI: 10.1161/hypertensionaha.108.127290
• 发表时间: 2009-04-01
• 期刊: HYPERTENSION
• 影响因子: 8.3
• 作者: Miyachi, Masaaki;Yazawa, Hiroki;Nagata, Kohzo
• 通讯作者: Nagata, Kohzo

Frequency, predictors and outcome of stent fracture after sirolimus-eluting stent implantation

• DOI: 10.1016/j.ijcard.2007.12.067
• 发表时间: 2009-04-17
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: Umeda, Hisashi;Gochi, Tomoko;Murohara, Toyoaki
• 通讯作者: Murohara, Toyoaki

Long-Term Administration of Nifedipine Attenuates Cardiac Remodeling and Diastolic Heart Failure in Hypertensive Rats

长期服用硝苯地平可减轻高血压大鼠的心脏重塑和舒张性心力衰竭

• 发表时间: 2009
• 期刊: European Journal of Pharmacology (in press)
• 作者: Yamada T;Cheng XW;et.al.
• 通讯作者: et.al.