Elucidation of molecular mechanisms for the regulation of immune response by reconstruction of microenvironment and analyses of transcription factors and their networks

通过微环境重建和转录因子及其网络分析阐明免疫反应调节的分子机制

基本信息

批准号：
21390077
负责人：
SHIMIZU Akira
金额：
$ 11.73万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009-04-01 至 2013-03-31
项目状态：
已结题

项目摘要

It is essential for proper for proper progression of immune reaction that construction of specific microenvironment and harmonized function of a variety of immuno-competent cells. It is tried to elucidate molecular mechanisms of such immune reaction by reconstruction of such microenvironment in vitro and analyses of transcription factors and their networks regulated by such microenvironment.An in vitro culture system that very efficiently induces class switching to IgA was established. It was found that Runx transcription factors are essential for IgA class switching and they act downstream of signals from retinoic acid TGF-beta1, and that Runx3 is essential for differentiation and maturation of regulatory T cells.

特定微环境的构建和多种免疫活性细胞的协调功能对于免疫反应的正常进行至关重要。试图通过重建这种体外微环境并分析这种微环境调节的转录因子及其网络来阐明这种免疫反应的分子机制。建立了一种非常有效地诱导向IgA类别转换的体外培养系统。研究发现，Runx 转录因子对于 IgA 类别转换至关重要，它们在视黄酸 TGF-β1 信号的下游发挥作用，而 Runx3 对于调节性 T 细胞的分化和成熟至关重要。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

DOI：
10.4049/jimmunol.1000848
发表时间：
2010-08-15
期刊：
JOURNAL OF IMMUNOLOGY
影响因子：
4.4
作者：
Tanaka, Satoshi;Maeda, Shinji;Sakaguchi, Shimon
通讯作者：
Sakaguchi, Shimon

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety.

DOI：
10.1186/1479-5876-9-55
发表时间：
2011-05-08
期刊：
Journal of translational medicine
影响因子：
7.4
作者：
Ido A;Moriuchi A;Numata M;Murayama T;Teramukai S;Marusawa H;Yamaji N;Setoyama H;Kim ID;Chiba T;Higuchi S;Yokode M;Fukushima M;Shimizu A;Tsubouchi H
通讯作者：
Tsubouchi H

Id2 controls chondrogenesis acting downstream of BMP signaling during maxillary morphogenesis

Id2 在上颌形态发生过程中控制软骨形成，作用于 BMP 信号下游

DOI：
发表时间：
2012
期刊：
Bone
影响因子：
4.1
作者：
Sakata-Goto;T.;Takahashi;K.;Kiso;H.;Huang;B.;Tsukamoto;H.;Takemoto;M.;Hayashi;T.;Sugai;M.;Nakamura;T.;Yokota;Y.;Shimizu;A.;Slavkin;H.;Bessho;K.
通讯作者：
K.

Runx3 is required for full activation of regulatory T cells to prevent colitis-assocfated tumor formation.

Runx3 是调节性 T 细胞完全激活以防止结肠炎相关肿瘤形成所必需的。