Integrative studies on the mechanism of central and peripheral fatigue manifestation and the development of foods that have effects of anti-fatigue and fast restoration from fatigue

中枢与外周疲劳表现机制的综合研究及抗疲劳、快速恢复疲劳食品的开发

• 批准号: 21380082
• 负责人: INOUE Kazuo
• 金额: $ 12.48万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380082/
• 关键词: 疲労; 脳内報酬系; エネルギー代謝

By using spontaneous lever-pressing behavior for intracranial self stimulation in rats, behavioral motivation could quantitatively be determined. Physical loads which caused fatigue in rats has also been shown to cause decreases in motivation, in other words, increases in brain reward threshold. Additionally psychological loads to rats has caused increases in brain reward threshold and this suggested the manifestation of feeling of fatigue by psychological stress.κ-opioid, a kind of endogenous opioids, was elucidated to increase brain reward threshold and to decrease spontaneous motor activities in rats. On the other hand,κ-opioid antagonists depressed the decreases in spontaneous motor activities after low-intensity exercise load. These findings suggested the involvement of endogenousκ-opioid to manifestation of feeling of fatigue.The inhibition of energy production from fat in peripheral tissues was elucidated to cause activation of transforming growth factor-beta in the brain via vagus nerve and to lead to fatigue-like behavior in rats.

通过使用自发的杠杆行为来对大鼠负载的颅内自刺激，导致大鼠的疲劳也导致动机的减少，大脑奖励的增加，使大鼠的大鼠增加。一种疲劳 - apio ID（一种内源性阿片类药物）被阐明以增加大脑奖励阈值并减少大鼠的自发运动性促进症。 d内源性κ阿片类药物参与表现出疲劳的表现。外周组织对能量产生的抑制作用是被固定的，从而导致通过迷走神经神经神经神经神经神经神经神经神经神经神经转化的生长因子β的激活大鼠的神经疲劳样行为。

项目成果

Intracranial self-stimulation(ICSS,脳内自己刺激)を用いた新規疲労測定法の確立

颅内自刺激（ICSS）疲劳测量新方法的建立

• 发表时间: 2011
• 作者: 久保健一;宇野雄太;宮田千加;大坪由佳;蔡晃植;上野聡子
• 通讯作者: 上野聡子

Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity

• DOI: 10.1016/j.physbeh.2010.06.006
• 发表时间: 2010-10-05
• 期刊: PHYSIOLOGY & BEHAVIOR
• 影响因子: 2.9
• 作者: Fujikawa, Teppei;Fujita, Ryo;Inoue, Kazuo
• 通讯作者: Inoue, Kazuo

Fatigue Science for Human Health

疲劳科学促进人类健康

• 发表时间: 2008
• 作者: Yasui T;Yada K;Mosialos G;Kieff E;Kikutani H;K. Kondo
• 通讯作者: K. Kondo

疲労物質としての脳内TGF-β

大脑中的TGF-β作为疲劳物质

• 发表时间: 2010
• 期刊: 体育の科学
• 作者: Inaka K;Takahashi S;Aritake K;Tsurumura T;Furubayashi N;Yan B;Hirota E;Sano S;Sato M;Kobayashi T;Yoshimura Y;Tanaka H;Urade Y.;井上和生
• 通讯作者: 井上和生

ICSS(脳内自己刺激)を用いた新規疲労測定法の確立

利用ICSS（脑内自刺激）建立新的疲劳测量方法

• 发表时间: 2011
• 作者: 永吉充弘;井上和生;伏木亨
• 通讯作者: 伏木亨