Mechanical properties and cell proliferation characteristic of functionally graded porous composite materials for bone tissue regeneration

用于骨组织再生的功能梯度多孔复合材料的力学性能和细胞增殖特性

• 批准号: 21360054
• 负责人: TODO Mitsugu
• 金额: $ 8.57万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21360054/
• 关键词: 材料設計; プロセス; 物性; 評価; 生体材料; 複合材料; 再生医療; 骨再生; 多孔質材料; 間葉系幹細胞; 多孔質構造

PLLA based scaffolds with reinforced structures have been developed for bone tissue regeneration. Four different kinds of reinforcements, dense shell, porous shell, one beam and two beams, have been introduced and it was found that the compressive modulus and strength are dramatically improved. It was also found that addition of bioactive ceramics such as HA and.-TCP into the PLLA matrix greatly improve the cell proliferation and ALP activity of the scaffold. Collagen/β-TCP scaffold has also been developed to improve bioactivity. This composite scaffold hybridized with stem cells was found to show better cell proliferation and differentiation behavior and have higher mechanical property than pure collagen scaffold with stem cells. It was also clarified that compressive mechanical stimulus can improve the cell proliferation and ALP activity within scaffolds.

基于PLLA的脚手架结构化已开发用于骨组织再生，一个梁和两个梁，发现压缩模量和强度也大大改善了。 PLLA矩阵Grix Grix还开发了胶原蛋白的细胞泛滥。也澄清了压缩机械刺激可以改善细胞的刺激。

项目成果

The variation of mechanical characteristic of collagen scaffold with mesechymal stem cell

间充质干细胞胶原支架力学特性的变化

• 发表时间: 2011
• 作者: K. Murota;Keisuke Tanaka;Takaaki Arahira and Mistugu Todo
• 通讯作者: Takaaki Arahira and Mistugu Todo

Development and characterization of reinforced poly(L-lactide) scaffolds for bone tissue engineering

• DOI: 10.1007/s10856-011-4289-4
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
• 影响因子: 3.7
• 作者: Park, Joo-Eon;Todo, Mitsugu
• 通讯作者: Todo, Mitsugu

Compressive Mechanical, Properties and Microstructure of Porous PLLA/PCL Polymer Blend and PLLA/HAp Composite Material

多孔PLLA/PCL聚合物共混物和PLLA/HAp复合材料的压缩力学、性能和微观结构

• 发表时间: 2009
• 作者: Joo-Eon Park;Mitsugu Todo
• 通讯作者: Mitsugu Todo

複合構造化による吸収性多孔質材料の高強度化

通过复合结构提高吸收性多孔材料的强度

• 发表时间: 2010
• 作者: Makoto SASAKI;Junichi IKENO;朴冑彦,東藤貢
• 通讯作者: 朴冑彦,東藤貢

骨組織形成による多孔質バイオセラミックスの力学特性変化に関する研究

骨组织形成引起的多孔生物陶瓷力学性能变化的研究

• 发表时间: 2010
• 作者: 荒平高章;東藤貢;名井陽
• 通讯作者: 名井陽