Linkage analysis between intraoral circumstances and obesity involved by adipokines in patients of Down syndrome

唐氏综合征患者脂肪因子相关口腔环境与肥胖的关联分析

• 批准号: 21592599
• 负责人: YAMAGUCHI Noboru
• 金额: $ 3.16万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592599/
• 关键词: ダウン症; 肥満; アディポネクチン; 口腔内環境; 鶴蝕; 歯周疾患; 唾液; 齲蝕; トリソミー; 歯石; IgA; 齲蝕リスク; アディポサイトカイン; 歯周病; 口腔粘膜疾患; 歯垢

In this study, we carried out the oral examination and several tests for 30 outpatients of Down syndrome who obtained informed consents in our University Hospital. All of them were very poor in their oral hygiene, and 28 patients clearly showed gingivitis. The salivary buffering capacity of them was low. As a result with the analysis of salivary pH and mineral components, the values of Na^<+> and K^(+) in Down' s patients were higher than them in normal ones, though they were not statistically significant. Moreover, salivary adiponectin levels in Down' s patients were not significant compared with them in normal ones. Actually, in our study, we could not get a significant relationship between adiponectin and Down syndrome. However, we need to make clear whether obesity in Down syndrome might affect for an occurrence and progression of oral diseases.

在这项研究中，我们对30位唐氏综合症的门诊患者进行了口试，并在我们的大学医院获得了知情同意。他们的口腔卫生中都很贫穷，28例患者清楚地表现出牙龈炎。它们的唾液缓冲能力很低。结果，通过分析唾液pH和矿物质成分，在正常患者的患者中，na^<+>和k^（+）的值在正常患者中比它们高，尽管它们没有统计学意义。此外，与正常患者相比，向下患者的唾液脂联素水平并不显着。实际上，在我们的研究中，我们无法在脂联素和唐氏综合症之间建立显着的关系。但是，我们需要清楚唐氏综合症的肥胖症是否可能会影响口腔疾病的发生和进展。

项目成果

Regulation of globular adiponectin-induced apoptosis by reactive oxygen/nitrogen species in RAW264 macrophages

• DOI: 10.1016/j.freeradbiomed.2008.08.005
• 发表时间: 2008-11-01
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Akifusa, Sumio;Kamio, Noriaki;Yamashita, Yoshihisa
• 通讯作者: Yamashita, Yoshihisa

歯肉粘膜内に歯胚様組織の形成を認めた1例

牙龈粘膜内形成牙胚样组织一例

• 发表时间: 2009
• 作者: 松石裕美子;増田啓次;藤田裕美子;清島保;山口登;中村由紀;小林家吉;坂井英隆;野中和明
• 通讯作者: 野中和明

Involvement of the JAK-STAT Pathway and SOCS3 in the Regulation of Adiponectin-Generated Reactive Oxygen Species in Murine Macrophage RAW 264 Cells

• DOI: 10.1002/jcb.22745
• 发表时间: 2010-10-15
• 期刊: JOURNAL OF CELLULAR BIOCHEMISTRY
• 影响因子: 4
• 作者: Akifusa, Sumio;Kamio, Noriaki;Yamashita, Yoshihisa
• 通讯作者: Yamashita, Yoshihisa

生体肝移植術を予定された患児に重度の騙蝕を認めたため術前に多数歯を抜歯した1例

一名计划进行活体肝移植的患者因严重龋齿而在术前拔掉了多颗牙齿。

• 发表时间: 2010
• 作者: 増田啓次;山口登;中村由紀;山座治義;野中和明
• 通讯作者: 野中和明

代表的な遺伝性疾患と対応一ダウン症児の臨床的対応

典型遗传病及其应对——唐氏综合症儿童的临床治疗

• 发表时间: 2010
• 期刊: DENTAL DIAMOND
• 作者: 山口登;野中和明
• 通讯作者: 野中和明