The transerelational research of the epoch-making in hard tissue regeneration with the rapidly proliferated iPS cells

快速增殖的iPS细胞在硬组织再生方面具有划时代意义的跨相关研究

基本信息

批准号：
21592427
负责人：
IKEDA Takeshi
金额：
$ 3万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Making an induced pluripotent stem cell by reprograming the mouse origined fibroblast with four kinds of gene was able to differentiate into varios cells became possible as an epoch-making result of the research in Japan, and, in addition, the establishment of human iPS cell was reported in the human skin fibroblast. Then, the cell is gathered from the patient' s organization now, the cell taken out to the outside of the body is induced to the iPS cell that has a versatile differentiation, and it differentiates into a necessary cell again. The achievement at the early stage of" True cell transplant treatment" without the immunity rejection that the cell is cultured by three dimensions by using the technology of the systems engineering in vitro, it is assumed to be a medical treatment of regenerating the tissue by transplantation of their cells to organization. Then, this research has used the chitosan that is the natural, organic biomaterials as scaffold of the iPS cell transplant system aiming at clinical practical application after 3-4 years. This aimed the development and the establishment of the hard tissue regeneration, especially alveolar bone and dentin.

日本研究的划时代成果，通过用四种基因重新编程小鼠来源的成纤维细胞来制造诱导多能干细胞，使之能够分化为多种细胞，这成为可能，此外，人类 iPS 细胞的建立也成为可能。据报道，在人类皮肤成纤维细胞中。然后，现在从患者的组织中收集细胞，将取出到体外的细胞诱导为具有多种分化能力的iPS细胞，并再次分化为所需的细胞。利用系统工程技术在体外立体培养细胞，无免疫排斥的“真正的细胞移植治疗”早期成果，被认为是通过移植再生组织的医疗方法他们的细胞组织。然后，本研究采用天然有机生物材料壳聚糖作为iPS细胞移植系统的支架，旨在经过3-4年的临床实际应用。这旨在发展和建立硬组织再生，特别是牙槽骨和牙本质。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Growth factor release from chitosan sponge as a scaffold for tissue engineering

作为组织工程支架的壳聚糖海绵释放生长因子

DOI：
发表时间：
2010
期刊：
影响因子：
0
作者：
Ikeda T;Ikeda K
通讯作者：
Ikeda K

Early gene expression analyzed by a genome microarray and real-time PCR in osteoblasts cultured with a 4-META/ MMA-TBB adhesive resin sealer

通过基因组微阵列和实时 PCR 分析使用 4-META/MMA-TBB 粘合树脂密封剂培养的成骨细胞中的早期基因表达

DOI：
发表时间：
2009
期刊：
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
影响因子：
0
作者：
Syudo M;Yamada S;Yanagiguchi K;Matsunaga T;Hayashi Y
通讯作者：
Hayashi Y

Chitosan and Fish Collagen as Biomaterials for Regenerative Medicine

DOI：
10.1016/b978-0-12-416003-3.00006-8
发表时间：
2012-01-01
期刊：
ADVANCES IN FOOD AND NUTRITION RESEARCH, VOL 65: MARINE MEDICINAL FOODS: IMPLICATIONS AND APPLICATIONS - ANIMALS AND MICROBES
影响因子：
0
作者：
Hayashi, Yoshihiko;Yamada, Shizuka;Ikeda, Takeshi
通讯作者：
Ikeda, Takeshi

組織再生用キトサン由来多孔性担体の特性について

用于组织再生的壳聚糖衍生多孔载体的特性